| 荧光原位杂交法对胃癌组织HER-2基因状态的检测 |
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| 引用本文： | 钟山,余英豪,黄红浪,刘伟,陈娟. 荧光原位杂交法对胃癌组织HER-2基因状态的检测[J]. 世界华人消化杂志, 2011, 0(2): 132-137 |
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| 作者姓名： | 钟山 余英豪 黄红浪 刘伟 陈娟 |
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| 作者单位： | 中国人民解放军南京军区福州总医院病理科;厦门大学附属第一医院病理科; |
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| 摘 要： | 目的:比较荧光原位杂交(FISH)法与免疫组织化学(IHC)染色法检测胃癌组织HER-2基因状态的一致性.方法:选择本课题组前期IHC染色法检测775例胃腺癌标本中HER-2蛋白表达为(2+)及(3+)的病例,应用FISH法对HER-2基因扩增情况进行验证.结果:FISH结果显示,86例HER(3+)标本中,60例存在...
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| 关 键 词： | 胃癌 人类表皮生长因子受体2 免疫组织化学染色法 荧光原位杂交法 检测 |
Evaluation of HER-2 gene status in gastric cancer by fluorescence in situ hybridization |
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| Shan Zhong,Ying-Hao Yu,Wei Liu,Juan Chen. Evaluation of HER-2 gene status in gastric cancer by fluorescence in situ hybridization[J]. World Chinese Journal of Digestology, 2011, 0(2): 132-137 |
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| Authors: | Shan Zhong Ying-Hao Yu Wei Liu Juan Chen |
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| Affiliation: | Shan Zhong,Ying-Hao Yu,Wei Liu,Juan Chen,Department of Pathology,Fuzhou General Hospital of Nanjing Military Command of Chinese PLA,Fuzhou 350025,Fujian Province,China Hong-Lang Huang,Xiamen First Hospital,Xiamen University,Xiamen 361003,China |
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| Abstract: | AIM: To compare immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) for detection of HER-2/neu gene status in gastric cancer.METHODS: HER-2 protein expression was examined by IHC in 775 gastric adenocarcinoma specimens.The amplification of HER-2 gene in gastric cancer specimens which were demonstrated to be HER-2 (2+) and (3+) by IHC was detected by FISH.RESULTS: There are 60 cases of gene amplification in 86 HER-2 (3+) specimens (69.77%),and in 26 cases of HER-2 (3+) specimens without ... |
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| Keywords: | Gastric cancer Human epidermal growth factor-2 Immunohistochemistry Fluorescence in situ hybridization Detection |
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