| 2型糖尿病中国地鼠脂肪肝相关胰岛素抵抗的形成机制 |
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| 引用本文： | 李国生,刘栩晗,黄澜,朱华,刘亚莉,马春梅. 2型糖尿病中国地鼠脂肪肝相关胰岛素抵抗的形成机制[J]. 世界华人消化杂志, 2011, 0(5): 457-466 |
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| 作者姓名： | 李国生 刘栩晗 黄澜 朱华 刘亚莉 马春梅 |
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| 作者单位： | 大连医科大学附属第一医院病理科; |
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| 摘 要： | 目的:研究2型糖尿病中国地鼠脂肪肝相关胰岛素抵抗的形成机制.方法:采用高脂饮食及结合小剂量链脲菌素(STZ)的方法建立肥胖胰岛素抵抗地鼠和2型糖尿病中国地鼠模型.应用基因表达芯片技术检测模型地鼠肝脏中基因表达谱的变化,并应用实时定量PCR进行验证.结果:基因芯片结果显示在胰岛素抵抗地鼠和糖尿病地鼠脂肪变的肝脏中,代谢相...
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| 关 键 词： | 肝X受体 固醇调节元件结合蛋白 过氧化物酶体增殖体激活受体 2型糖尿病 胰岛素抵抗 中国地鼠 |
Mechanisms underlying the development of hepatic steatosis-related insulin resistance in Chinese hamsters with type 2 diabetes |
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| Guo-Sheng Li,Xu-Han Liu,Lan Huang,Hua Zhu,YaLi Liu,Chun-Mei Ma. Mechanisms underlying the development of hepatic steatosis-related insulin resistance in Chinese hamsters with type 2 diabetes[J]. World Chinese Journal of Digestology, 2011, 0(5): 457-466 |
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| Authors: | Guo-Sheng Li Xu-Han Liu Lan Huang Hua Zhu YaLi Liu Chun-Mei Ma |
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| Affiliation: | Guo-Sheng Li,Xu-Han Liu,Lan Huang,Hua Zhu,YaLi Liu,Chun-Mei Ma,Department of Pathology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning Province,China |
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| Abstract: | AIM:To investigate the mechanisms underlying the development of hepatic steatosis-related insulin resistance in Chinese hamsters with type 2 diabetes.METHODS:Insulin-resistant obese Chinese hamsters and Chinese hamsters with type 2 diabetes were generated by feeding a high-fat diet with or without low-dose streptozotocin.Then we investigated the alterations in hepatic gene expression profiles by microarray analysis followed by real-time RT-PCR confirmation.RESULTS:Microarray analysis indicated that,in insul... |
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| Keywords: | Liver X receptor Sterol regulatory element-binding protein Peroxisome proliferator-activated receptor Type 2 diabetes Insulin resistance Chinese hamster |
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