| 丙型肝炎病毒感染实验模型的研究新进展 |
| |
| 引用本文： | 薛宏丽,冯国和,窦晓光. 丙型肝炎病毒感染实验模型的研究新进展[J]. 世界华人消化杂志, 2011, 0(12) |
| |
| 作者姓名： | 薛宏丽 冯国和 窦晓光 |
| |
| 作者单位： | 中国医科大学附属盛京医院感染科; |
| |
| 基金项目： | “十一五”重大传染病防治基金资助项目,No.2008ZX10002-013~~ |
| |
| 摘 要： | 丙型肝炎病毒(HCV)感染是继乙型肝炎病毒之后引起慢性肝炎、肝硬化以及肝细胞癌的又一主要病因.HCV易感宿主选择有限,至今尚不能建立稳定、易行的HCV感染细胞及动物模型系统,使得病毒变异性、复制机制、与宿主蛋白相互作用以及新药与疫苗研发等相关研究受到极大限制.本文就近年来围绕持续稳定的HCV体外细胞或动物感染模型的研究新进展作一综述.
|
| 关 键 词： | 动物感染模型 细胞模型 丙型肝炎病毒 |
New advances in the development of experimental models of hepatitis C virus infection |
| |
| Abstract: | Hepatitis C virus (HCV) infection is another common cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma after hepatitis B virus. It is very difficult to study the variety and replication of HCV and interplay between HCV and the host and to develop new antiviral drugs and vaccines against HCV infection because of lack of susceptible hosts and stable and convenient experimental models of HCV infection. In this paper, we review recent advancesin the development of experimental models of H... |
| |
| Keywords: | Animal infection models Cell models Hepatitis C virus |
| 本文献已被 CNKI 等数据库收录！ |
|
