| Wnt信号转导通路与肝纤维化关系的研究现况 |
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| 引用本文： | 万赞燕,胡国信. Wnt信号转导通路与肝纤维化关系的研究现况[J]. 世界华人消化杂志, 2011, 0(17): 1761-1766 |
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| 作者姓名： | 万赞燕 胡国信 |
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| 作者单位： | 南昌大学第一附属医院感染科; |
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| 基金项目： | 国家自然科学基金资助项目,No.30760230~~ |
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| 摘 要： | 阻断该通路可以 Wnt 信号转导通路是近年来分子生物学、细抑制癌细胞的增殖和诱导凋亡.胞生物学和肿瘤研究中的一大热点,其参与调 控细胞分化、癌变、凋亡及机体免疫、应激 等多种病理生理过程.目前许多关于癌症方面 的研究均已证实,阻断Wnt 信号通路可以诱导 癌症细胞的凋亡.肝纤维化的发生与多种信号 通路的激活相关,有研究...
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| 关 键 词： | Wnt信号转导通路 肝星状细胞 肝纤维化 |
Relationship between the Wnt signaling pathway and liver fibrosis: recent research status |
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| Zan-Yan Wan,Guo-Xin Hu. Relationship between the Wnt signaling pathway and liver fibrosis: recent research status[J]. World Chinese Journal of Digestology, 2011, 0(17): 1761-1766 |
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| Authors: | Zan-Yan Wan Guo-Xin Hu |
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| Affiliation: | Zan-Yan Wan,Guo-Xin Hu,Department of Infectious Diseases,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China |
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| Abstract: | The Wnt signaling pathway participates in many physiological and pathological processes such as cell differentiation, carcinogenesis, apoptosis, immunity, and stress. Many studies have shown that blockage of the Wnt signaling pathway can induce cancer cell apoptosis. Many signaling pathways are associated with the pathogenesis of liver fibrosis. Several studies have shown that the Wnt signaling pathway is involved in the formation of liver fibrosis. Blockage of the Wnt signaling pathway could inhibit the pr... |
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| Keywords: | Wnt signaling pathway Hepatic stellate |
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