| 甲胎蛋白的生物学功能 |
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| 引用本文： | 李朝英,李刚. 甲胎蛋白的生物学功能[J]. 世界华人消化杂志, 2011, 0(14): 1436-1440 |
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| 作者姓名： | 李朝英 李刚 |
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| 作者单位： | 北京大学医学部生物化学与分子生物学系; |
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| 基金项目： | 国家自然科学基金资助项目,No.81072710; 北京市自然科学基金资助项目,No.7101006~~ |
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| 摘 要： | 甲胎蛋白(AFP)不仅是肝细胞癌诊断的重要标志物,还在肝癌细胞的生长、增殖及凋亡等过程中发挥着重要的生物学作用.除了胞外的配体结合和运输功能,以及作为生长调控因子刺激肿瘤细胞生长外,细胞内的AFP还可以通过和转录因子或一些关键蛋白之间发生相互作用而作为信号分子参与对下游基因的转录调控或对信号通路产生影响.这些为我们研究...
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| 关 键 词： | 甲胎蛋白 肝细胞癌 信号分子 生物学功能 |
Biological functions of alphafetoprotein |
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| Chao-Ying Li,Gang Li. Biological functions of alphafetoprotein[J]. World Chinese Journal of Digestology, 2011, 0(14): 1436-1440 |
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| Authors: | Chao-Ying Li Gang Li |
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| Affiliation: | Chao-Ying Li,Gang Li,Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing 100191,China |
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| Abstract: | Alpha-fetoprotein(AFP) is a well-known biomarker for the diagnosis of hepatocellular carcinoma.Extracellular AFP can act as a carrier to transport a variety of ligands or as a growth regulator to control the growth of tumor cells,while intracellular AFP can bind to and interact with transcription factors or some key proteins and function as a signal molecule to regulate cell proliferation or apoptosis.This paper provides novel insights into the mechanisms underlying the role of AFP in carcinogenesis and tum... |
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| Keywords: | Alpha-fetoprotein Liver cancer Signal molecule Biological function |
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