| 香芹酚对肝细胞癌HepG2细胞凋亡的诱导作用及其分子机制 |
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| 引用本文： | 殷清华,庄英帜. 香芹酚对肝细胞癌HepG2细胞凋亡的诱导作用及其分子机制[J]. 世界华人消化杂志, 2011, 0(15): 1555-1560 |
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| 作者姓名： | 殷清华 庄英帜 |
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| 作者单位： | 南华大学第一附属医院肿瘤内科; |
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| 摘 要： | 目的:探讨香芹酚(carvacrol,CV)对人肝癌细胞(HepG2)的抗癌作用及其分子机制.方法:予以不同浓度的香芹酚(0.00、0.05、0.10、0.20、0.40 mmol/L)处理肝癌细胞HepG2后,采用四甲基偶氮唑蓝(MTT)比色法检测细胞活力;Hoechst33258染色法及流式细胞仪(FCM)技术检测...
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| 关 键 词： | 香芹酚 HepG2 细胞凋亡 丝裂原活化蛋白激酶 |
Molecular mechanisms involved in carvacrol-induced apoptosis in human hepatocellular carcinoma cell line HepG2 |
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| Qing-Hua Yin,Ying-Zhi Zhuang. Molecular mechanisms involved in carvacrol-induced apoptosis in human hepatocellular carcinoma cell line HepG2[J]. World Chinese Journal of Digestology, 2011, 0(15): 1555-1560 |
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| Authors: | Qing-Hua Yin Ying-Zhi Zhuang |
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| Affiliation: | Qing-Hua Yin,Ying-Zhi Zhuang,Department of Oncology,the First Affiliated Hospital of Nanhua University,Hengyang 421001,Hunan Province,China |
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| Abstract: | AIM:To investigate whether carvacrol induces apoptosis in human hepatocellular carcinoma cell line HepG2 and to explore possible molecular mechanism involved.METHODS:After cultured HepG2 cells were incubated with different concentrations of carvacrol(0.00,0.05,0.10,0.20,0.40 mmol/L) for 24 or 48 h,cell viability was analyzed by MTT assay;cellular morphological alterations were observed after Hoechst33258 staining;apoptosis was detected by flow cytometry(FCM);and protein expression of mitogen-activated prote... |
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| Keywords: | Carvacrol HepG2 cells Apoptosis Mitogen-activated protein kinase |
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