| 黏着斑激酶在结直肠癌中的研究进展 |
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| 引用本文： | 张丹华,周建平. 黏着斑激酶在结直肠癌中的研究进展[J]. 世界华人消化杂志, 2011, 0(12) |
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| 作者姓名： | 张丹华 周建平 |
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| 作者单位： | 中国医科大学附属第一医院普通外科教研室胃肠外科; |
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| 基金项目： | 辽宁省教育厅科技基金资助项目,No.2008809~~ |
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| 摘 要： | 黏着斑激酶(focal adhe sion kinase,FAK)是一种非受体酪氨酸激酶,他作为整合素介导的信号传导过程中的中心分子与多个信号通路相交通,参与细胞的生长、增殖、损伤修复及凋亡等多种生物学行为.FAK在结直肠癌中高表达,在正常大肠组织中呈弱阳性或阴性.FAK可能成为结直肠癌治疗的一个重要靶点,抑制FAK的功能可以阻断多条与肿瘤相关的信号通路.
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| 关 键 词： | 黏着斑激酶 结直肠癌 信号通路 |
Role of focal adhesion kinase in the pathogenesis of colorectal carcinoma |
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| Dan-Hua Zhang,Jian-Ping Zhou. Role of focal adhesion kinase in the pathogenesis of colorectal carcinoma[J]. World Chinese Journal of Digestology, 2011, 0(12) |
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| Authors: | Dan-Hua Zhang Jian-Ping Zhou |
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| Affiliation: | Dan-Hua Zhang,Jian-Ping Zhou,Department of General Surgery,the First Hospital of China Medical University,Shenyang 110001,Liaoning Province,China |
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| Abstract: | Focal adhesion kinase (FAK) was initially identif ied as a nonreceptor protein tyrosine kinase localized to the focal contact protein clusters. This enzyme has been shown to facilitate generation of integrin-stimulated signals to downstream targets. It has been reported that activation of FAK leads to a number of processes, including cell attachment, migration, proliferation, and survival. The expression of FAK in colon carcinoma is significantly higher than that in matched cancer-adjacent normal tissue, su... |
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| Keywords: | Focal adhesion kinase Colorectal carcinoma Signal pathway |
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