| SDF-1及其受体CXCR4在结直肠癌组织中的表达及与PCNA的关系 |
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| 引用本文： | 郭云娣,李小宁,李明,何影娟. SDF-1及其受体CXCR4在结直肠癌组织中的表达及与PCNA的关系[J]. 世界华人消化杂志, 2011, 0(18) |
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| 作者姓名： | 郭云娣 李小宁 李明 何影娟 |
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| 作者单位： | 苏州卫生职业技术学院苏州检验医学生物技术重点实验室;苏州市立医院;苏州九龙医院; |
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| 摘 要： | 目的:研究结直肠癌组织中基质细胞衍生因子(SDF-1)及其受体(CXCR4)的表达与结直肠癌生物学行为以及与核增殖抗原(PCNA)间的关系,以探讨SDF-1/CXCR4的表达以及PCNA在结直肠癌侵袭、转移中的生物学意义.方法:在结直肠癌组织芯片上,应用免疫组织化学Envision法检测SDF-1/CXCR4和PCNA的表达水平,分析SDF-1、CXCR4和PCNA在结直肠癌的表达与患者淋巴结转移状态、肿瘤分化程度的关系及其相互关系.结果:SDF-1的阳性表达率为60.2%(77/128),CXCR4的阳性表达率为43.8%(56/128).结直肠癌组织SDF-1及CXCR4的阳性表达率均高于癌旁正常黏膜组织(P<0.01).PCNA的阳性表达率为44.5%(57/128).SDF-1/CXCR4和PCNA与患者淋巴结转移状态、肿瘤分化程度相关(均P<0.05),SDF-1/CXCR4与PCNA之间呈正相关(r=0.084,P=0.005;r=0.087,P=0.030).结论:同时检测结直肠癌组织中的SDF-1/CXCR4和PCNA的表达对判断肿瘤的恶性程度和估计预后有一定意义.
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| 关 键 词： | 结直肠肿瘤 基质细胞衍生因子1 C×C趋化因子受体 核增殖抗原 组织芯片片 |
Expression of stromal cell derived factor-1,CXC chemokine receptor 4 and PCNA proteins in human colorectal carcinoma |
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| Yun-Di Guo,Xiao-Ning Li,Suzhou Health College,Suzhou Key Laboratory of Biotechnology for Laboratory Medicine,Suzhou ,Jiangsu Province,China Ming Li,Suzhou Municipal Hospital,Suzhou ,China Ying-Juan He,Suzhou Kowloon Hospital,Suzhou ,China. Expression of stromal cell derived factor-1,CXC chemokine receptor 4 and PCNA proteins in human colorectal carcinoma[J]. World Chinese Journal of Digestology, 2011, 0(18) |
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| Authors: | Yun-Di Guo Xiao-Ning Li Suzhou Health College Suzhou Key Laboratory of Biotechnology for Laboratory Medicine Suzhou Jiangsu Province China Ming Li Suzhou Municipal Hospital Suzhou China Ying-Juan He Suzhou Kowloon Hospital Suzhou China |
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| Affiliation: | Yun-Di Guo,Xiao-Ning Li,Suzhou Health College,Suzhou Key Laboratory of Biotechnology for Laboratory Medicine,Suzhou 215009,Jiangsu Province,China Ming Li,Suzhou Municipal Hospital,Suzhou 215008,China Ying-Juan He,Suzhou Kowloon Hospital,Suzhou 215021,China |
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| Abstract: | AIM:To investigate the correlations of the expression of stromal cell derived factor-1(SDF-1),CXC chemokine receptor 4(CXCR4),and proliferating cell nuclear antigen(PCNA) with the clinicobiological parameters of human colorectal carcinoma.METHODS:The expression of SDF-1/CXCR4 and PCNA proteins in human colorectal carcinoma was measured by immunohistochemistry on tissue microarrays.The relationship of expression of SDF-1/CXCR4 and PCNA proteins with the clinicobiological parameters of human colorectal carcin... |
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| Keywords: | Colorectal carcinoma Stromal cell derived factor-1 CXC chemokine receptor 4 Proliferating cell nuclear antigen Tissues microarray |
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