| 大肠腺瘤与大肠腺癌肿瘤相关基因的差异表达 |
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| 引用本文： | 曾伟,南清振,戴益琛,朱小三,陈章兴,谢军培,傅育卡,林园园.大肠腺瘤与大肠腺癌肿瘤相关基因的差异表达[J].世界华人消化杂志,2011(8):868-873. |
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| 作者姓名： | 曾伟 南清振 戴益琛 朱小三 陈章兴 谢军培 傅育卡 林园园 |
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| 作者单位： | 中国人民解放军174医院消化内科;广州市南方医院消化科;南昌大学研究生院医学部; |
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| 基金项目： | 2009年度军区医学科技创新课题基金资助项目,No.09MA066; 厦门市科技计划医疗卫生创新基金资助项目,No.3502Z20084031~~ |
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| 摘 要： | 目的:探索大肠腺瘤与大肠腺癌差异表达的肿瘤相关基因.方法:利用基因芯片技术筛选大肠腺瘤与大肠腺癌差异表达的肿瘤相关基因,比较两组基因特点,寻找大肠腺癌重要致病基因,并以RT-PCR对部分差异表达基因进行检测来验证芯片结果.结果:(1)大肠腺瘤差异表达的肿瘤相关基因9个,均上调;(2)大肠腺癌差异表达的肿瘤相关基因47个...
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| 关 键 词： | 大肠腺瘤 基因芯片技术 大肠腺癌 |
Differential expression of tumor-related genes between colorectal adenoma and adenocarcinoma |
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| Wei Zeng,Qing-Zhen Nan,Yi-Chen Dai,Xiao-San Zhu,Zhang-Xin Chen,Jun-Pei Xie,Yu-Ka Fu,Yuan-Yuan Lin.Differential expression of tumor-related genes between colorectal adenoma and adenocarcinoma[J].World Chinese Journal of Digestology,2011(8):868-873. |
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| Authors: | Wei Zeng Qing-Zhen Nan Yi-Chen Dai Xiao-San Zhu Zhang-Xin Chen Jun-Pei Xie Yu-Ka Fu Yuan-Yuan Lin |
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| Institution: | Wei Zeng,Qing-Zhen Nan,Yi-Chen Dai,Xiao-San Zhu,Zhang-Xin Chen,Jun-Pei Xie,Yu-Ka Fu,Yuan-Yuan Lin,Department of Gastroenterology,the 174th Hospital of Chinese PLA,Xiamen 361003,Fujian Province,China Qing-Zhen Nan,Nanfang Hospital Affi liated to Southern Medical University,Guang-zhou 510515,Guangdong Province,China Xiao-San Zhu,Medical Department of Graduate College of Nanchang University,Nanchang 330006,Jiangxi Province,China |
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| Abstract: | AIM: To identify differentially expressed tumorrelated genes between colorectal adenoma and adenocarcinoma.METHODS: Gene chip technology was used to screen differentially expressed tumorrelatedgenes between colorectal adenoma and adeno- carcinoma.RT-PCR was then performed to validate microarray results.RESULTS: Nine differentially expressed tumorrelated genes were expressed only in colorectal adenoma,all of which were up-regulated.Forty- seven differentially expressed tumor-related genes were expressed only... |
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| Keywords: | Colorectal adenoma Gene chip technology Colorectal adenocarcinoma |
| 本文献已被 CNKI 等数据库收录！ |
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