| JNK信号通路介导MDR1/P-gp调控人结肠癌多药耐药 |
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| 引用本文： | 隋华,周利红,殷佩浩,王炎,范忠泽,周树峰,李琦. JNK信号通路介导MDR1/P-gp调控人结肠癌多药耐药[J]. 世界华人消化杂志, 2011, 0(9): 892-898 |
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| 作者姓名： | 隋华 周利红 殷佩浩 王炎 范忠泽 周树峰 李琦 |
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| 作者单位： | 上海中医药大学附属普陀医院;上海中医药大学中西医结合肿瘤介入研究所;南佛罗里达大学药学院; |
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| 基金项目： | 国家自然科学基金资助项目,No.308734; 上海市科委基金资助项目,No.10ZR1427400;No.10140902600; 上海市教委科研创新基金资助项目,No.09YZ132; 上海市重点学科基金资助项目,No.S30302~~ |
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| 摘 要： | 目的:探讨在人结肠癌多药耐药细胞株HCT8/V中JNK信号传导通路与多药耐药1(MDR1)基因表达的关系.方法:MTT法检测人结肠癌多药耐药细胞株HCT8/V及其敏感株HCT8细胞对多种抗肿瘤药物的敏感性;抑制JNK信号通路的激活后,采用双荧光素酶活性报告基因检测MDR1启动子转录活性的表达;实时荧光定量PCR检测MD...
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| 关 键 词： | 结肠癌 多药耐药1 P-糖蛋白 c-Jun氨基末端激酶 信号转导通路 |
JNK signal transduction pathway regulates MDR1/P-glycoprotein-mediated multidrug resistance in colon carcinoma cells |
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| Hua Sui,Li-Hong Zhou,Pei-Hao Yin,Yan Wang,Zhong-Ze Fan,Qi Li,Putuo Hospital,Shanghai University of Traditional Chinese Medicine. JNK signal transduction pathway regulates MDR1/P-glycoprotein-mediated multidrug resistance in colon carcinoma cells[J]. World Chinese Journal of Digestology, 2011, 0(9): 892-898 |
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| Authors: | Hua Sui Li-Hong Zhou Pei-Hao Yin Yan Wang Zhong-Ze Fan Qi Li Putuo Hospital Shanghai University of Traditional Chinese Medicine |
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| Affiliation: | Hua Sui,Li-Hong Zhou,Pei-Hao Yin,Yan Wang,Zhong-Ze Fan,Qi Li,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Institute of Interventional Cancer,Shanghai 200062,China Shu-Feng Zhou,Department of Pharmaceutical Sciences,College of Pharmacy,University of South Florida,Tampa 33612,Florida,USA |
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| Abstract: | |
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| Keywords: | Colon carcinoma Multidrug resistance 1 P-glycoprotein c-Jun NH2-terminal kinase Signal transduction pathway |
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