肝动脉栓塞后肝功能改变及病理基础

目的：探讨单纯全肝动脉末梢栓塞对正常肝组织的影响。方法：用５０～１００ｕｍ明胶海棉微球末梢栓塞１０条犬的全肝动脉，栓后１、３、７、１４和２８ｄ，分别处死１或２条犬，观察组织病理改变，处死前抽血化验肝功能，动态观察肝功能的变化及相应的病理改变。结果：栓后１ｄＧＰＴ、ＧＯＴ及ＡＫＰ升高，超过正常值范围，肝细胞变性、坏死。栓后３ｄＧＰＴ、ＧＯＴ升至高峰，肝细胞变性严重，坏死明显。然后下降，２周后恢复。结论：肝动脉栓塞对肝细胞的急性损害是暂时的

Hepatic Functional Changes and Their Pathologic Basis inExperimental Hepatic Artery Embolization(HAE)

Objective:To ascertain normal hepatocytes and hepatic function change after completely hepatic peripheral artery embolization.Methods:Whole hepatic arteriae of 10 dogs were embolized with 50-100 um gelfoam microsphere.Then one or two dogs were killed at 1,3,7,14 and 28 days after embolization respectively.The liver function were determined just before the execution of dogs and studied together with corresponding pathological changes of the liver.Results:GPT,GOT and AKP elevated beyond normal figure,hepatocytes were degeneration and necrosis after completely peripheral HAE,Following 3 days,GPT.GOT rose to the heightest value,hepatocytes were degeneration and necrosis obviously Following 14 days,GPT.GOT returned to normal level,hepatocytes proliferated,many of hepatocytes were normal.Conclusion:Acute damage of liver cells after HAE was present only for a short period of time.