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| 缺血耐受大鼠局灶性脑梗死后血管再生的实验研究 | |
| 引用本文： | 韩巨,孙燕,张涛,张新娟,孙晋浩.缺血耐受大鼠局灶性脑梗死后血管再生的实验研究[J].山东大学学报(医学版),2011,49(3):8-12. |
| 作者姓名： | 韩巨 孙燕 张涛 张新娟 孙晋浩 |
| 作者单位： | 1. 山东大学附属千佛山医院神经内科,济南,250014 2. 山东省医学影像研究所,济南,250021 3. 山东大学医学院解剖学教研室,济南,250012 |
| 基金项目： | 山东省自然科学基金资助项目(Y2006C86) |
| 摘 要： | 目的研究缺血预处理(IP)对局灶性脑梗死后血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)表达以及微血管密度的影响,探讨IP脑保护作用机制。方法利用线栓法建立局灶性脑缺血大脑中动脉闭塞模型(MCAO),MCAO 10min作为IP,IP后48h制作永久性大脑中动脉梗死(PMCAO)模型,进行神经功能评分、测定脑组织含水量、观察脑组织病理改变、检测VEGF及MMP-9表达和脑组织微血管密度(MVD)变化。结果 IP显著减轻PMCAO大鼠神经功能及组织学损害,降低PMCAO后MMP-9的表达,减轻脑水肿,VEGF表达及微血管密度增加。结论 IP对其后PMCAO有明显的保护作用,能诱导脑缺血耐受(IT)的产生,脑IT的神经保护作用与脑梗死后血管再生密切相关。 |
| 关 键 词： | 缺血预处理 脑缺血发作 短暂性 明胶酶B 血管内皮生长因子 血管再生 |
Angiogenesis after focal cerebral infarction in rats with brain ischemic tolerance |
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| HAN Ju,SUN Yan,ZHANG Tao,ZHANG Xin-juan,SUN Jin-hao.Angiogenesis after focal cerebral infarction in rats with brain ischemic tolerance[J].Journal of Shandong University:Health Sciences,2011,49(3):8-12. | |
| Authors: | HAN Ju SUN Yan ZHANG Tao ZHANG Xin-juan SUN Jin-hao |
| Institution: | HAN Ju1,SUN Yan1,ZHANG Tao1,ZHANG Xin-juan2,SUN Jin-hao3 (1.Department of Neurology,Qianfoshan Hospital Affiliated to Shandong University,Jinan 250014,China,2.Shandong Institute of Medical Imaging,Jinan 250021,3.Department of Anatomy,School of Medicine,Shandong University,Jinan 250012,China) |
| Abstract: | Objective To study the effect of ischemic preconditioning(IP) on expressions of vascular endothelial growth factor(VEGF) and matrix metalloproteinase-9(MMP-9) and the micro-vessel density(MCV) after focal cerebral infarction in rats,and to explore the mechanism of neuro-protection of IP on subsequent focal cerebral infarction.Methods Transient middle cerebral artery occlusion(MCAO) for 10 min was used as IP,and reperfusion for 48 h was carried out after IP and before permanent MCAO(PMCAO) to produce ischemi... |
| Keywords: | Ischemic preconditioning Ischemic attack transient Gelatinase B Vascular endothelial growth factor Angiogenesis |
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