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| 淋巴性脑水肿大鼠孤束背内侧亚核Glu、GABA及GAD67的时程变化 | |
| 引用本文： | 宋希俊,郑延红,刘新民,王立为,赵晓民,夏作理. 淋巴性脑水肿大鼠孤束背内侧亚核Glu、GABA及GAD67的时程变化[J]. 山东大学学报(医学版), 2011, 49(3): 64-67,72 |
| 作者姓名： | 宋希俊 郑延红 刘新民 王立为 赵晓民 夏作理 |
| 作者单位： | 1. 中国医学科学院,北京协和医学院药用植物研究所药理毒理中心,北京,100193 2. 兵器工业北京北方医院,北京,100089 3. 泰山医学院生命科学研究所,山东,泰安,271000 |
| 摘 要： | 目的观察淋巴性脑水肿(LBE)模型大鼠孤束背内侧亚核(dmNTS)内谷氨酸(Glu)、γ-氨基丁酸(GABA)的改变及谷氨酸脱羧酶亚型67(GAD67)表达的时程变化,并探讨其意义。方法应用免疫组化方法,观察LBE大鼠dmNTS内Glu、GABA及GAD67在颈淋巴引流阻滞后不同时间点的变化情况。结果 LBE组Glu改变及GAD67表达在颈淋巴引流阻滞后1 d即开始升高,至第7天达高峰,后逐渐下降,于21 d恢复;而GABA在颈淋巴引流阻滞后1d即开始降低,至第7天降至最低,后逐渐升高,于21d恢复。结论 LBE大鼠dmNTS内Glu和GA-BA的改变可能参与了血压调节功能的降低;GAD67早期表达逐渐增加,可能是机体的一种代偿性机制,有助于神经递质水平的平衡和恢复。 |
| 关 键 词： | 淋巴性脑水肿 孤束背内侧亚核 谷氨酸 γ-氨基丁酸 谷氨酸脱羧酶亚型67 大鼠 |
Temporal alterations of Glu,GABA and GAD67 in dmNTS in rats with lymphatic brain edema |
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| SONG Xi-jun,ZHENG Yan-hong,LIU Xin-min,WANG Li-wei,ZHAo Xiao-min,XIA Zuo-li. Temporal alterations of Glu,GABA and GAD67 in dmNTS in rats with lymphatic brain edema[J]. Journal of Shandong University:Health Sciences, 2011, 49(3): 64-67,72 | |
| Authors: | SONG Xi-jun ZHENG Yan-hong LIU Xin-min WANG Li-wei ZHAo Xiao-min XIA Zuo-li |
| Affiliation: | 1.Center for Pharmacology and Toxicology,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100193,China; 2.Beijing North Hospital,China North Industries Group Corporation,Beijing 100089,China; 3.Institute of Life Sciences,Taishan Medical College,Tai′an 271000,Shandong,China) |
| Abstract: | Objective To investigate temporal alterations of glutamic acid(Glu),gamma-aminobutyric acid(GABA) and glutamic acid decarboxylase isoform 67(GAD67) in the dorso-medial nucleus of tractus solitarii(dmNTS) in rats with lymphatic brain edema(LBE) induced by cervical lymphatic blockage(CLB). Methods Sprague-Dawley(SD) rats were randomly divided into three groups: the normal group,the sham operated group and the LBE group.Glu,GABA and GAD67 in dmNTS in rats were detected by immuohistochemistry 1,3,7,11,15 and 21... |
| Keywords: | Lymphatic brain edema Dorsomedial nucleus of tractus solitarii Glutamic acid Gamma-aminobutyric acid Glutamic acid decarboxylase isoform 67 Rats |
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