粪便钙卫蛋白在全消化系统疾病鉴别诊断中的意义

背景：粪便钙卫蛋白（FC）对鉴别诊断肠道炎症性疾病有较高的临床价值，但其在全消化系统疾病中的意义尚不完全清楚。目的：探讨FC在全消化系统疾病鉴别诊断中的意义。方法：纳入2011年6～8月南京军区南京总医院溃疡性结肠炎、克罗恩病、结肠息肉、肠易激综合征、食管炎、食管息肉、慢性胃炎、胃、十二指肠溃疡、急性胰腺炎、胃淋巴瘤患者共47例，以12名健康人作为对照，采用ELISA方法测定FC水平。以受试者工作特征（ROC）曲线分析FC检测的诊断效能。结果：在下消化道疾病中，溃疡性结肠炎和克罗恩病患者的FC水平显著高于结肠息肉和肠易激综合征患者（P〈0．01）．FC检测鉴别这两组疾病的ROC曲线下面积为0．952。食管炎、食管息肉、胃淋巴瘤患者的FC水平显著高于慢性胃炎、胃、十二指肠溃疡、急性胰腺炎患者（P〈0．01）。结论：FC作为一种非侵入性检测方法，对消化系统疾病的鉴别诊断具有一定临床价值。

Significance of Fecal Calprotectin in Differential Diagnosis of Whole Spectrum of Digestive System Diseases

Background: Fecal calprotectin(FC) possesses a high clinical value in differential diagnosis of inflammatory diseases of intestine,but its significance in whole spectrum of digestive system diseases is not completely known.Aims: To investigate the significance of FC in differential diagnosis of whole spectrum of digestive system diseases.Methods: Forty-seven patients with ulcerative colitis,Crohn’s disease,colonic polyp,irritable bowel syndrome,esophagitis,esophageal polyp,chronic gastritis,gastric ulcer,duodenal ulcer,acute pancreatitis or gastric lymphoma were enrolled from June 2011 to August 2011 at Nanjing General Hospital of Nanjing Military Command,and 12 healthy subjects were served as controls.Expression of FC was determined by ELISA method.Receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficiency of FC determination.Results: In lower gastrointestinal diseases,expression of FC in patients with ulcerative colitis and Crohn’s disease was higher than that in patients with colonic polyp and irritable bowel syndrome(P<0.01);the area under ROC curve for differential diagnosis of these two groups was 0.952.Expression of FC in patients with esophagitis,esophageal polyp and gastric lymphoma was higher than that in patients with chronic gastritis,gastric ulcer,duodenal ulcer and acute pancreatitis(P <0.01).Conclusions: Determination of FC as a noninvasive method can be helpful for the differential diagnosis of digestive system diseases.