超声引导下酒精硬化治疗卵巢子宫内膜异位囊肿前后卵巢功能变化的研究

目的 探讨超声引导下酒精硬化治疗卵巢子宫内膜异位囊肿前后卵巢功能的变化.方法 超声引导下酒精硬化治疗的卵巢子宫内膜异位囊肿患者100例,以年龄为界,是否双侧发病分为4组,A组30例:年龄＜35岁,单侧囊肿；B组20例:年龄≥35岁,单侧囊肿；C组25例:年龄＜35岁,双侧囊肿；D组25例:年龄≥35岁,双侧囊肿.比较各组治疗前、治疗后3个月、6个月患者血清促卵泡成熟激素(FSH)、雌二醇(E2)水平,超声观察卵巢体积、窦卵泡数和卵巢间质血流分布,评估患侧卵巢功能的变化.结果 与治疗前比较,C组、D组治疗后3个月、6个月FSH逐渐下降,E2水平逐渐上升,差异有统计学意义(P＜0.05).A组、B组治疗后3个月、6个月FSH、E2均在正常范围内.治疗后各组3个月、6个月患侧卵巢体积增大,间质血流速度增快,阻力指数下降,卵巢间质血流由0、Ⅰ级为主升至Ⅱ、Ⅲ级为主,A组、C组卵巢的窦卵泡数增加,差异均有统计学意义(P＜0.05).结论 超声引导下酒精硬化治疗卵巢子宫内膜异位囊肿能够达到保护和修复卵巢功能的目的.

Changes of ovarian function of anhydrous ethanol sclerotherapy for ovarian endometriotic cysts

Objective To investigate the ovarian function change after anhydrous ethanol sclerotherapy for ovarian endometriotic cysts guided by ultrasound. Methods One hundred cases of ovarian chocolate cyst were retrospectively analyzed after Anhydrous ethanol sclerotherapy. These patients were divided into four groups according to cyst number and age,including group A (n =30, unilateral ovarian endometriotic cyst age < 35year), group B (n =20, unilateral ovarian endometriotic cyst, age≥35year) , group C(n=25, bilateral ovarian endometriotic cyst, age<35year) and group D(n=25,bilateral ovarian endometriotic cyst age ≥35year). The level of FSH and E 2 in the serum at 3rd and 6th month and ovarian volume, antral follicle number, peak systolic velocity (PSV)in ovarian stroma and resistance index (RI) were evaluated in patients in each group post-treatment. Results The serum FSH level at 3rd and 6th month post-operation were significantly decreased while E 2 was apparently increased in group C and group D. There was significant difference in ovarian volume(P<0.05), antral follicle number, PSV,RI at 3rd and 6th month post -operation. Ovarian stromal arterial flow was maily on grade 0, Ⅰ and changed to grade Ⅱ、Ⅲ post-treatment. Conclusion This study indicates that the ovarian function will be improved after ethanol sclerotherapy.