| 叶绿素衍生物光动力学疗法对不同肿瘤细胞的体外杀伤效应 |
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| 引用本文： | 魏薇,张友忠,孔北华,江森.叶绿素衍生物光动力学疗法对不同肿瘤细胞的体外杀伤效应[J].山东大学学报(医学版),2002,40(3):271-272. |
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| 作者姓名： | 魏薇 张友忠 孔北华 江森 |
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| 作者单位： | 山东大学齐鲁医院妇产科 |
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| 基金项目： | 九五国家重点攻关课题 ( 96 90 8 0 4 0 2 )，山东省优秀中青年基金资助课题 ( 9918) |
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| 摘 要： | 目的 :研究叶绿素衍生物 (CPD4 )光动力学疗法 (PDT)对人卵巢癌细胞、肝癌细胞、胆囊癌细胞的体外杀伤效应。方法 :应用MTT比色分析法研究PDT CPD4对人卵巢癌细胞 (3AO)、肝癌细胞 (HCC)、胆囊癌细胞 (GBC SD)的光动力杀伤效应。结果 :PDT对人卵巢癌细胞、肝癌细胞、胆囊癌细胞杀伤效应明显 ,CPD4的光动力学杀伤效应与药物浓度呈正相关 ,并与激光能量有关。结论 :光动力学疗法对人卵巢癌细胞、肝癌细胞、胆囊癌细胞有明显杀伤效应 ,且与激光能量、药物浓度有关
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| 关 键 词： | 光动力学疗法 肿瘤 体外研究 |
| 文章编号： | 1671-7554(2002)03-0271-02 |
| 修稿时间： | 2001年9月12日 |
Efficacy of Chlorophyll derivative(CPD4)photodynamic therapy against different neoplastic cells |
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| WEI Wei,ZHANG You-zhong,KONG Bei-hua,et al.Efficacy of Chlorophyll derivative(CPD4)photodynamic therapy against different neoplastic cells[J].Journal of Shandong University:Health Sciences,2002,40(3):271-272. |
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| Authors: | WEI Wei ZHANG You-zhong KONG Bei-hua |
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| Abstract: | Objective: To study the efficacy of Chlorophyll derivative(CPD4) photodynamic therapy(PDT) against cells of human ovarian ,liver and gallbladder cancers . Method: MTT colormetric assay was adopted in the study of the photodynamic cytotoxicity of human ovarian cancer cells 3AO, liver cancer cells HCC and gallbladder cancer cells GBC-SD. Results: PDT was effective in killing cells of human ovarian,liver and gallbladder cancers ,and its efficacy was correlated to the laser energy and the concentration of the drug. Conclusion:PDT has apparently destructed against cells of human ovarian,liver and gallbladder cancer, and its efficacy was correlated to the laser energy and the concentration of the drug. |
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| Keywords: | Photodynamic therapy Carcinoma In vitro |
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