Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice. |
| |
| Authors: | S Ahmad W L Anderson K T Kitchin |
| |
| Affiliation: | MD-68, Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. |
| |
| Abstract: | Adult female B6C3F1 mice were given 720 mg/kg of DMA by oral gavage at one of three times (2 h, 15 h, or at both 21 and 4 h) before sacrifice. Significant (P < 0.05) decreases in liver GSH and GSSG contents (15-37%) were observed. Some evidence of DMA-induced hepatic DNA damage (at the P < 0.10 level only) was observed. Pulmonary and hepatic ODC activities were reduced (19-59%) by DMA treatment. Overall, these biochemical studies show that mice are much less responsive to DMA than rats. |
| |
| Keywords: | |
|
|
