DNA ploidy study of resected hepatocellular carcinoma in cirrhotic liver |
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Authors: | Joaquin Balsells Isabel Caragol Elena Allende Isabel Diaz Ramon Charco Jose-Luis Lazaro Enrique Murio Carlos Margarit |
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Affiliation: | aDepartment of Surgery Biochemistry Unit, Hospital General Universitari Vall d'Hebron Universidad Autónoma de Barcelona, Spain;bPathology Department, Hospital General Universitari Vall d'Hebron Universidad Autónoma de Barcelona, Spain |
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Abstract: | Background/Aims: Results of several studies on DNA ploidy as a prognostic indicator in hepatocellular carcinoma are contradictory. The present study analysed the correlations between DNA ploidy of resected hepatocellular carcinoma and tumour characteristics, tumour recurrence, risk factors and survival.Methods: Tumoural DNA ploidy of hepatocellular carcinomas from 37 patients with cirrhosis who underwent curative tumour resection was studied by flow cytometry.Results: A diploid pattern was found in 23 hepatocellular carcinomas (62.2%) and an aneuploid pattern in 14 (37.8%). The tumour recurrence rate did not differ statistically between diploid (69.6%) and aneuploid (50%) hepatocellular carcinomas. The only prognostic variable with significant difference in DNA pattern was the histologic tumour type; the majority of non-trabecular tumours were aneuploid while most trabecular hepatocellular carcinomas had a diploid DNA pattern. Actuarial survival at 1, 2, 3 and 4 years of patients with diploid and aneuploid tumours was 69.6%, 40.6%, 16.2% and 0%, and 69.3%, 59.4%, 49.5% and 32.9%, respectively (log rank p=0.1927).Conclusion: These results indicate that DNA ploidy has no prognostic value in hepatocellular carcinoma. |
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Keywords: | Cirrhosis DNA ploidy Flow cytometry Hepatocellular carcinoma. |
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