| 大鼠肝再生过程中增殖细胞核抗原的表达 |
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| 引用本文： | 刘铜,王冬梅. 大鼠肝再生过程中增殖细胞核抗原的表达[J]. 蚌埠医学院学报, 2005, 30(4): 293-294,297 |
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| 作者姓名： | 刘铜 王冬梅 |
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| 作者单位： | 蚌埠医学院,组织胚胎学教研室,安徽,蚌埠,233003;安徽省宿州市卫生学校,234000 |
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| 摘 要： | 目的:探讨大鼠肝再生过程中肝细胞增殖细胞核抗原(PCNA)表达的变化. 方法:建立肝切除动物模型,用免疫组织化学法、图像分析仪检测肝细胞PCNA的表达. 结果:PCNA强阳性肝细胞数及其总灰度值在肝大部切除后24 h明显增高,肝细胞阳性表达率在48 h达到峰值,至120 h趋于正常水平.结论:PCNA强阳性肝细胞呈规律性变化,提示残余肝可再生.
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| 关 键 词： | 肝再生 免疫组织化学 增殖细胞核抗原 大鼠 |
| 文章编号： | 1000-2200(2005)04-0293-02 |
Expression of proliferating cell nuclear antigen during liver regeneration process after partial-hepatectomy in rats |
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| LIU Tong,WANG Dong-mei. Expression of proliferating cell nuclear antigen during liver regeneration process after partial-hepatectomy in rats[J]. Journal of Bengbu Medical College, 2005, 30(4): 293-294,297 |
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| Authors: | LIU Tong WANG Dong-mei |
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| Abstract: | Objective:To observe the expression of proliferating cell nuclear antigen(PCNA) during liver regeneration process after partial-hepatectomy in rats.Methods:ABC immunohistochemistry methods and anti-PCNA monoclonal antibody were used to reveal the expression of PCNA in the rat liver slice.Results:The number of PCNA positive cells and the grey degree numerical value increased remarkably 24 h after hepatectomy,and the expression rate of heptocytes increased to peak valuer 48 h after hepatectomy. Conclusions:The PCNA strong positive cells show regular change afterhepatectomy,which suggests that the remained liver cells can regenerate. |
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| Keywords: | hepatic regeneration immunohistochemistry proliferating cell nuclear antigen rats |
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