二维与三维超声心动图斑点追踪技术检测乳腺癌蒽环类药物心脏毒性的可行性研究

目的:探讨二维与三维斑点追踪技术以及实时三维超声心动图在早期检测蒽环类药物所致心脏毒性中的价值,并评估其可行性.方法:对乳腺癌患者于蒽环类药物化疗前、化疗第3周期及化疗结束后行超声心动图检查,以3D LVEF结果为评价标准,统计分析各参数在评估心脏毒性中的临床价值.结果:共92例乳腺癌患者纳入研究.常规超声心动图以及2...

The feasibility of two-dimensional and three-dimensional echocardiogrophie speckle tracking imaging in detecting cardiotoxicity of anthracycline in breast cancer

Objective:To explore the value of two-dimensional and three-dimensional speckle tracking imaging(2 D/3 D-STI) and real-time three-dimensional echocardiography(RT-3 DE) in early detection of cardiotoxicity caused by anthracycline and to evaluate their feasibility.Methods:The patients with breast cancer were examined by echocardiography before chemotherapy, the third cycle of chemotherapy and after chemotherapy.Using the result of 3 D LVEF as evaluation criteria, the clinical value of each parameter in the evaluation of cardiotoxicity was analyzed.Results:A total of 92 breast cancer patients were included in the study.The feasibility of conventional echocardiography and 2 D GLS was better, while RT-3 DE and 3 D-STI were less feasible before and after chemotherapy.The difference of 2 D LVEF in different chemotherapy cycles was not statistically significant.2 D GLS,3 D GLS,3 D GRS and 3 D GAS were significantly reduced from the end of the third cycle, and lasted until the end of chemotherapy.E/A,3 D LVEF and 3 D GCS decreased significantly after chemotherapy.The ROC curve showed that 3 D GAS had the highest diagnostic efficacy for cardiotoxicity of anthracycline, with a cutoff value of-30.8%,sensitivity and specificity of 79% and 92% respectively.Conclusion:3 D-STI can early identify subclinical cardiac insufficiency caused by anthracycline, but its feasibility is not good in some breast cancer patients, and its clinical application is limited.For such patients, 2 D GLS can provide more accurate information than 2 D LVEF.