注射用硝普钠在葡萄糖注射液中稳定性考察

目的 考察注射用硝普钠与5％葡萄糖注射液配伍的稳定性.方法 将注射用硝普钠,根据临床应用需要配制成溶液,在不同环境和不同放置时间,考察配伍溶液的性状、pH值、不溶微粒、紫外-可见吸收光谱、硝普钠含量等.结果 避光套避光,在20℃、35℃时,注射用硝普钠与5％葡萄糖注射液配伍后26 h内是稳定的;不避光任何条件下溶液均不稳定;溶液的稳定性与硝普钠浓度（0.2 -0.05 mg/mL）无关,与温度（20℃、35℃）有一定关联,但与光照强度和光照时间密切相关.结论 在避光条件下,注射用硝普钠与5％葡萄糖注射液配伍26 h内稳定.

Study on compatible stability of nitroprusside sodium for injection with glucose injection

Objective To investigate the compatible stability of nitroprusside sodium for injection（SNP） when mixed with 5% glucose injection. Methods SNP was prepared into solution according to clinical use. In different envi- ronment and different storage time, compatible solution appearance, pH, insoluble particles, ultraviolet visible absorption spectra, the content of sodium nitroprusside were studied. Results SNP solutions of 5 % glucose injection were stable for 26 hours after preparation in shading circumstances at 20 ℃ or 35 ℃. If light was not avoided, in any conditions, the solution was very unstable, the stability of solution was independent of the concentration （0. 2 -0. 1 mg/mL）, but had a certain relationship with temperature （20 ℃, 35℃）, and was closely related to light, strength and time. Conclusion In the dark condition,sodium ntropmsside for injection was stable within 26 h after mixing with 5% glucose injection.