| 心肌缺血再灌注损伤的主要机制与相关药物治疗的研究进展 |
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| 引用本文： | 徐盟. 心肌缺血再灌注损伤的主要机制与相关药物治疗的研究进展[J]. 辽宁药物与临床, 2014, 0(8): 1052-1056 |
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| 作者姓名： | 徐盟 |
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| 作者单位： | 中国医科大学,沈阳110001 |
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| 摘 要： | 缺血性心肌病在治疗后可能发生缺血再灌注损伤,受损心肌的损伤程度加重,梗死面积扩大,这种现象的发生与多种机制有关,包括：钙超载、氧自由基增多、炎症反应等.随着心肌缺血的治疗技术的提高,缺血再灌注时期的治疗已成为缺血性心肌病的治疗重点,因此,针对防治该时期的药物研发也已成为重点.常见药物作用机制包括：减轻钙超载、抗炎症反应、抗氧自由基和改善能量代谢等.本文旨在对MIRI不同病理机制和相关药物的研究进展进行阐述.
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| 关 键 词： | 心肌缺血再灌注损伤(MIRI) 钠离子/钙离子交换蛋白 氧自由基 炎症因子 |
Research on main mechanisms of MIRI and related drug therapy |
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| XU Meng. Research on main mechanisms of MIRI and related drug therapy[J]. Liaoning Pharmacy and Clinical Remedies, 2014, 0(8): 1052-1056 |
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| Authors: | XU Meng |
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| Affiliation: | XU Meng( China Medical University, Shenyang 110001, China) |
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| Abstract: | Ischemia-reprefusion injury （IRI）often occurred after ischemia myocardial is treated. When IRI occurred, the damaging degree of myocardial aggravated and infarction area expanded. The phenomenon is associated with a variety of mechanisms, including ： overloading calcium, increased oxygen free radicals, inflammation, etc. With the improvement of MIRI＇ s treating technology, treatments during MIRI become a key to treat ischemia myocardial. So re search of drugs for preventing or treating disease during MIRI has become the key point. Common mechanisms of drugs include：reducing calcium overloaded, anti-inflammation, resisting oxygen free radicals and improving energy meatabolism, etc. This article aims to summarize different pathologic mechanisms of MIRI and recent research of related drugs. |
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| Keywords: | MIRI NCX OFR Inflammation factor TNF-a |
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