阿托伐他汀治疗非酒精性脂肪性肝病的疗效观察

目的 观察阿托伐他汀治疗非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的临床疗效.方法 179例患者随机分为3组,低剂量组口服阿托伐他汀,10 mg/d;高剂量组口服阿托伐他汀,20 mg/d;对照组使用水林佳胶囊,105 mg/次,3次/d.共治疗16周.对比3组治...

Curative Effect of Atorvastatin on Nonalcoholic Fatty Liver Disease

Objective To observe the curative effects of atorvastatin on nonalcoholic fatty liver disease（NAFLD）.Methods A total of 179 NAFLD patients were randomly divided into three groups.The low-dose group was administrated with atorvastatin 10 mg per day,the high-dose group was administrated with atorvastatin 20 mg per day,and the control group was administrated with silibinin capsule 105 mg per time,3 times per day.Before treatment,8 and 16 weeks after the treatment,the liver to spleen CT ratio,cholesterol（TC）,glycerin trilaurate（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,creatine kinase（CK）,liver function indexes including alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,alkaline phosphatase（ALP）,γ-glutamy transpeptidase（γ-GT）,indirect bilirubi（IBIL）,renal function indexes including creatinine（Cr）,routine indexes of blood,urine and stool and electrocardiogram（ECG） were detected respectively.Adverse effect was also observed.Results The total effective rate in the low-dose,high-dose and control groups were 93.75% and 92.98% and 91.38% respectively without significant difference（P0.05）.Lipid lowering effect was better,TC,TG and LDL-C were significantly decreased,and HDL-C was increased in atorvastatin treatment group,and better in high-dose group than in low-dose group.In high-dose group,several cases had digestive reaction which disappeared by drug administration after the meal and symptomatic therapy,3 cases had slight increase of aminotransferase,and 1 case had slight increase of CK.In low-dose group,1 case had slight increase of aminotransferase.No adverse event was observed in the control group.In all the three groups,no abnormal drug-related change in laboratory indexes including routine blood,urine and stool,liver function,renal function and ECG was observed.Conclusion Atorvastatin can treat NAFLD with hyperlipemia safely.High dose（20 mg/d） of atorvastatin has better curative effect than low dose（10 mg/d）.