弥漫大B细胞淋巴瘤中枢神经系统浸润的研究

目的：研究弥漫大B细胞淋巴瘤(DLBCL)中枢神经系统(CNS﹚浸润的危险因素。方法回顾性分析2013年1月＿2015年8月期间福建医科大学附属协和医院血液病研究所新诊断的年龄满18周岁的DLBCL患者。结合文献,对DLBCL患者发生CNS浸润的时间、高危因素进行回顾性分析。结果共分析173例患者,13例发生中枢神经系统浸润(7.5%﹚,5例在发病5个月内发生,8例在6个月后发生且均在1年内,4例表现为软脑膜受累,6例为脑实质受累,3例两者同时受累。高IPI评分、高LDH水平、结外病变≥2处、临床分期≥III期系CNS浸润的高危因素(P﹤0.05﹚。发生CNS浸润后患者平均生存时间为5.7个月。结论高危患者发生CNS浸润风险高,发生CNS浸润后患者预后差。

Clinical Study of Diffuse Large B Cells Lymphoma Central Nervous System Invasion

Objective To analysis the risk factors in diffuse large B-cell lymphoma patients with central nerve system in-filtration. Methods Newly diagnosed patients with DLBCL in Department of Hematology Fujian Medical University Union Hospital between Jan 2013 and Aug 2015 were reviewed. In combination with literatures, the time of CNS infiltration、high risk factors were retrospectively analyzed. Results A total of 173 DLBCL patients (aged ≥18years), 13patients (7.5%)had CNS infiltration .International Prognostic Index﹥2、elevated lactate dehydrogenase(LDH)、extranodal sites≥2、stage III or IV (P﹤0.05﹚. Median survival time after CNS infiltration was 5.7 months. Conclusion these patients with high risk factors has shown a higher incidence of CNS infiltration, CNS infiltration is associated with poor patient outcomes.