应用骨折风险因子评估工具识别绝经后女性骨质疏松症

目的应用世界卫生组织骨折风险因子评估工具（FRAX）识别绝经后女性骨质疏松症。方法在秦皇岛市第一医院进行骨密度测量的绝经后女性103名为研究对象，平均年龄（64．1±9．8）岁。采用问卷调查的方法，计算骨折风险（不应用骨密度）和亚洲人骨质疏松自我筛查工具（OSTA）指数。结果共检出骨质疏松症患者43例，骨质疏松组年龄明显高于非骨质疏松组（P〈0．01）。骨质疏松组OSTA指数明显低于非骨质疏松组，10年髋部骨折风险和主要骨质疏松性骨折风险明显高于非骨质疏松组（P〈0．01）。OSTA指数识别骨质疏松症的ROC曲线下面积为0．734（P=0．000），准确性中等。10年髋部骨折风险识别骨质疏松症的ROC曲线下面积为0．766（P=0．000），准确性中等。结论FRAX工具同样可用于识别绝经后女性骨质疏松症，但并不优于OSTA指数。

The discrimination of fracture risk assessment tool in the assessment of osteoporosis in postmenopausal women

Objective The aim of this study was to analyze the discrimination of fracture risk assessment tool in the assessment of osteoporosis in postmenopausal women. Methods 103 postmenopausal women （64. 1 ± 9. 8 years）, were recruited from the First Hospital of Qinhuangdao. Questionnaire survey was conducted. Bone mineral density was measured by dual energy x - ray absorptiometry. 10 - year probabilities of major fracture and hip fracture were calculated by the fracture risk assessment tool （without bone mineral density）. The index of osteoporosis self - assessment tool for Asians was also calculated. Results The age was old in osteoporotic group （P 〈 0. 01 ） . The level of OSTA was low in fracture group （P 〈 0.01 ）. 10 - year probabilities of major fracture and hip fracture were higher in osteoporutic group （P 〈 0. 01 ）. Receiver operating characteristic curve analysis also showed that OSTA （ Area under the curve ： 0. 734, P = 0. 000） and 10 -year probabilities of hip fracture （Area under the curve： 0. 766, P =0. 000） could identify osteoporosis. Conclusion Fracture risk evaluated by FRAX may be helpful to identify osteoporosis in postmenopausal women, but was not superior to OSTA.