高压氧干预对颈动脉弹性影响的定量评价

目的 应用回声跟踪( echo tracking,ET)技术对受试者双侧颈动脉参数进行分析,定量评价高压氧干预对颈动脉弹性的影响.方法 41例行高压氧治疗的患者为高压氧组,20名健康者为高气压组,另20名健康者为高流量组.前2组于进舱前及出舱后即刻、高流量组于吸氧前及吸氧后即刻,应用ET对双侧颈动脉弹性进行检测,检测参数包括血管的压力-应变弹性系数(Ep)、硬化参数(β)及血管顺应性(AC).结果 高压氧组干预后Ep[(112.38±50.94)kPa]及β值(8.29±3.66)较干预前均减小(129.04±52.4)kPa,(9,75±3.83),AC值增大[干预前(0.86±0.34) mm2/kPa,干预后(0.99±0.45)mm2/kpa],差异均有统计学意义(P＜0.01),高气压组干预后β及Ep较值进舱前减小,AC值较进舱前增加,差异均有统计学意义(P＜0.01或P＜0.05)；高流量组吸氧前后Ep、β及AC值差异均无统计学意义(P＞0.05);年龄＜40岁的高压氧组及高气压组干预后Ep、β及AC值均有改善,且高压氧组较高气压组改善更明显,2组比较差异有统计学意义(P＜0.05或P＜0.01).结论 高压氧干预即刻即可改善颈动脉弹性.

Quantitative evaluation for the effects of hyperbaric oxygen Intervention on carotid artery elasticity

Ohjectlve To evaluate quantitatively the effect of hyperbaric oxygen (HBO) on carotid artery elasticity with bilateral carotid artery parameters by echo tracking (ET).Methods Forty-one patients who received HBO therapy were assigned to the HBO group ( group 1 ),20 healthy subjects assigned to the hyperbaric air group ( group 2) and still another 20 healthy subjects were assigned to the high-flow oxygen therapy group ( group 3).The patients of group 1 breathed pure oxygen at 0.20 MPa for a duration of 60 min,and the subjects of group 3 breathed pure oxygen at normal pressure also for a duration of 60 rmin.For the first 2 groups,bilateral carotid artery elasticity was measured with ET,at a time right before entrance into the chamber and right after exit from the chamber; and for group 3,measurement was made with ET,at a time right before oxygen breathing and right after oxygen breathing.The measured data included vascular pressure-strain elasticity modulus (Ep),data of artery stiffness (β) and artery compliance (AC).Results For the HBO group,when patients came out of the chamber,Ep and β levels were significantly decreased,while AC data were significantly increased,with statistical significance,when compared with that of pre-HBO therapy[preintervention of HBO: Ep ( 129.04 ± 52.47 ) kPa,β: (9.75 ± 3.83),AC: ( 0,86 ± 0.34 ) mm2/kPa; postintervention of HBO: Ep: ( 112.38 ± 50.94 ) kPa,β: ( 8.29 ± 3.66 ),AC: (0.99 ± 0.45 ) mm2/kPa ]( P ＜0.0l ).For the hyperbaric air group,when subjects came out of the chamber,Ep and β levels were decreased,while AC data were increased,all with statistical significance,when compared with that before entrance into the chamber (P ＜ 0.0 l or P ＜ 0.05 ).For the high-flow oxygen therapy group,no differences could be detected in Ep,β and AC data measured both before and after oxygen breathing,without statistical significance ( P ＞0.05).For those in group 1 and group 2,with an age of less than 40,Ep,β and AC data all improved,when they came out of the chamber (P ＜0.01 or P ＜0,05 ),with HBO group having more significant improvement than the hyperbaric air group.And statistical significance could be noted,when a comparison was madebetween the two ( P ＜ 0.01 or P ＜ 0.05 ).Conclusions HBO intervention could improve carotid artery elasticity.