Correlations between digit ratio and infertility in Chinese men |
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Authors: | Hong Lu Zheng-hao Huo Yong-jie Liu Zhi-yun Shi Jun-li Zhao |
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Institution: | 1. Department of Medical Genetic and Cell Biology, Ningxia Medical University, Yinchuan 750004, China;2. Key Laboratory of Reproduction and Genetics in Ningxia, Yinchuan 750004, China;3. Key Laboratory of Fertility Preservation and Maintenance, Ningxia Medical University, Ministry of Education, Yinchuan 750004, China;4. Ningxia Women and Children Health Hospital, Yinchuan 750001, China;5. Medical Experimental Center in General Hospital, Ningxia Medical University, Yinchuan 750004, China;6. Reproductive Department of General Hospital, Ningxia Medical University, Yinchuan 750004, China |
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Abstract: | BackgroundDigit ratio, especially second to fourth digit ratio (2D:4D) is lower in men than in women. The ratios of digit may be established in utero and is negatively correlated with sperm counts and testosterone in men and positively correlated with estrogen in men and women.AimTo study whether the digit ratio (especially 2D:4D) are associated with the a + b ratio of sperm number in Chinese populations.MethodsPhotocopies of the two hands of 268 men (controls: 72; patients: 196) and seminal parameters of masturbatory semen samples were collected.ResultsThe mean values of digit ratio of the controls and the patients all presented a trend as 2D:3D < 2D:4D < 3D:4D < 2D:5D < 4D:5D < 3D:5D; the patients have higher mean values than controls; significant variances of 2D:3D, 3D:4D (left: P < 0.05; right: P ≤ 0.05) and 2D:4D (left: P < 0.001; right: P < 0.01) were found between two groups; there was a higher percentage of 2D > 4D in the patients; the relationship between 2D:4D and a + b ratio of sperm number in the patients was significant (P < 0.001).ConclusionDigit ratio, especially 2D:4D in the left hand maybe one of the important markers of infertility in men for early diagnosis. |
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Keywords: | Digit ratio Infertility Han nationality Marker |
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