Chronic fluphenazine treatment modifies circadian rhythms of neurotransmitter receptor binding in rat brain |
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Authors: | D. Naber Anna Wirz-Justice Marian S. Kafka |
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Affiliation: | (1) Biological Psychiatry Branch and Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, Md., USA;(2) Present address: Psychiatrische Klinik, Universität München, Federal Republic of Germany;(3) Psychiatrische Klinik, Universität Basel, Switzerland |
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Abstract: | Summary Binding to rat brain- and-adrenergic, muscarinic cholinergic, dopamine and opiate receptors was measured at 4-hour intervals throughout a 24-hour period in animals, chronically treated with fluphenazine, and in controls. Drug treatment significantly changed characteristics of the circadian rhythms in all 5 receptors. In the presence of the drug the 24-hour mean binding to the dopamine receptor was decreased; to the other 4 receptors it was increased. Moreover, there were changes in the timing of the maximal receptor binding (phase-position) and in the amplitude of the rhythms. These results extend previous studies, showing that chronic neuroleptic treatment not only affects the dopamine receptors, but also other neurotransmitter receptors, profoundly modifying their temporal organisation. |
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