| 食管癌组织侵袭脉管的免疫组织化学研究 |
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| 引用本文： | 王超,沈琼,王东煜.食管癌组织侵袭脉管的免疫组织化学研究[J].郑州大学学报(医学版),1991(3). |
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| 作者姓名： | 王超 沈琼 王东煜 |
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| 作者单位： | 河南医科大学癌前期研究室
(王超，沈琼)，河南医科大学癌前期研究室(王东煜) |
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| 摘 要： | 应用血型抗原A、B、H的单克隆抗体及先进的SABC(Streptavidin-biotin Complex)技术对常规处理的51例食管癌组织切片进行免疫组织化学研究.结果表明:该方法为脉管内皮细胞提供了稳定而清晰的染色.能更加客观地观察食管癌组织内部间质及周围组织中的癌栓.其显示脉管侵袭的阳性率为43.14%.明显高于HE染色的23.53%(P<0.01)。食管癌组织侵袭脉管与癌组织的分化程度、生长方式及淋巴结转移等有密切关系(P<0.05)。
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| 关 键 词： | ABH血型抗原 单克隆抗体 内皮细胞 脉管(血管和/或淋巴管)侵袭 食管癌 免疫组织化学 |
Immunohistochemistry in the identification of lymphatic and blood vessel invasion in carcinoma of the esophagus |
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| Wang Chao,Shen Qiong,Wang Dongyu.Immunohistochemistry in the identification of lymphatic and blood vessel invasion in carcinoma of the esophagus[J].Journal of Zhengzhou University: Med Sci,1991(3). |
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| Authors: | Wang Chao Shen Qiong Wang Dongyu |
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| Institution: | Wang Chao;Shen Qiong;Wang Dongyu Department of Precancerous Studies |
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| Abstract: | Monoclonal antibodies to ABH isoantigens and an advanced SABC staining technique were used tostudy the immunohistochemistry of 51 sections of formalinembedded esophageal tissues from patientswith advanced squamous cell carcinomas of the esophagus. The results indicated that this method pro-duced consistent and specific staining of endothelium cells in the vessels,could made an objective obser-vation of the mesenchyma in the tissue of esophageal carcinoma and the cancerous emboli in the pe-ripheral tissues. The positive rate of vascular invasion by using monoclonal antibodies and SABC stain-ing technique (43.14%) was higher than that by HE staining sections(23.53%) (P<0. 01). The re-sults showed vascular invasion of esophageal cancer tissues had close relation with their degrees of dif-ferentiation,growth patterns and metastasis to lymph nodes(P<0. 05). |
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| Keywords: | endothelial cells immunohistochemistry ABH isoantigens monoclonal antibodies vascular (lymphatic and/or blood vessel)invasion carcinoma of the esophagus |
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