In vitro replication of varicella-zoster virus in human retinal pigment epithelial cells |
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| Authors: | Schmidt-Chanasit Jonas Bleymehl Karoline Rabenau Holger F Ulrich Rainer G Cinatl Jindrich Doerr Hans Wilhelm |
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| Affiliation: | Institute of Medical Virology, Hospital of Johann Wolfgang Goethe University, D-60596 Frankfurt am Main, Germany. H.W.Doerr@em.uni-frankfurt.de |
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| Abstract: | Here we describe for the first time the productive in vitro infection of human retinal pigment epithelial cells by varicella-zoster virus (VZV), resulting in a typical cytopathic effect (CPE) that is characterized by enlarged cells with increased granularity. Depending on the CPE dissemination, high titers of up to 1.6 x 10(6) PFU of cell-free and cryostable VZV/ml can be recovered. |
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