清咽排毒颗粒的药效学研究

目的研究清咽排毒颗粒在解热、镇痛、抗炎、止咳、祛痰、体外抗菌、体外抗病毒等方面的作用,为其临床用于风热型急性咽炎提供了实验依据。方法选用2,4-二硝基苯酚致大鼠发热法、热板法、二甲苯所致小鼠耳廓肿胀法、氨水引咳法、小鼠酚红排泄法、最低抑菌浓度法和鸡胚内抗病毒法。结果清咽排毒颗粒对2,4-二硝基苯酚所致大鼠发热有显著的解热作用;对热板法引起的疼痛具有明显的镇痛作用;对二甲苯所致小鼠耳肿胀有明显的抑制作用;能明显抑制氨水引起的小鼠咳嗽,促进小鼠气管酚红排泄;对金黄色葡萄球菌、乙型溶血性链球菌、肺炎克雷伯氏菌、大肠杆菌、甲型流感病毒H1N1有一定抑制作用。结论清咽排毒颗粒具有解热、镇痛、抗炎、止咳、祛痰、体外抗菌、体外抗病毒等方面的作用。

Pharmacodynamic Study of Qingyan Paidu Granule

Objective To study the pharmacodynamic actions of Qingyan Paidu Granule about antipyretic,analgesic,anti-inflamatory,antitussive,expectorant,bacteriostasis,and antivirus.Methods Antipyretic action was evaluated with rat pyrogentic test induced by 2,4-dinitrophenol.Its analgesia action was investigated by hot plate test.Anti-inflammation action by using auricle swelling in mice caused by bimethylbenzene and antitussive effect by using cough-model in mice caused by ammonia were observed and the quantity of phenolred secreted from the mice's trachea were determined.Minimal inhibitory concentration test and antiviral effect by infecting chicken embryo with H1N1 were tested.Results Qingyan Paidu Granule had obvious antipyretic action,analgesic action, anti-inflammationy action,antitussive action,and expectorant action;and it had some inhibitory action to staphylococci,beta-hemolytic streptococci,pneumococcus,Escherichia coli,and influenza virus A with H1N1.Conclusion Qingyan Paidu Granule has evident effects of antipyretic,analgesia,anti-inflammation,antitussive,expectorant,bacteriostasis,and antivirus.