| 胞外体与肿瘤免疫治疗 |
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| 引用本文： | 孙静. 胞外体与肿瘤免疫治疗[J]. 白血病．淋巴瘤, 2012, 21(6): 373-375 |
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| 作者姓名： | 孙静 |
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| 作者单位： | 200090,上海交通大学医学院附属新华医院血液科 |
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| 摘 要： | 【摘要】 胞外体（EXO）是真核细胞晚期内体分泌到细胞外的小囊泡体，负载了来源细胞的膜分子，蛋白分子以及一些参与信号转导的分子。不同来源的EXO其所负载的蛋白成分不同，其生物学特性也有所差异。以树突细胞（DC）为代表的抗原递呈细胞（APC）以及肿瘤细胞释放的EXO在机体免疫调节以及肿瘤免疫治疗中的作用研究近年来取得了较大进展。就EXO 的生物学特性及其在肿瘤免疫治疗中研究进展作一综述。
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| 关 键 词： | 树突细胞 肿瘤细胞 胞外体 肿瘤免疫治疗 |
Exosomes and cancer immunotherapy |
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| SUN Jing. Exosomes and cancer immunotherapy[J]. Journal of Leukemia & Lymphoma, 2012, 21(6): 373-375 |
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| Authors: | SUN Jing |
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| Affiliation: | SUN Jing, HAO Si-guo. Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200090, China |
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| Abstract: | Exosomes are endosome-derived vesicles （40-100 nm） formed during the formation of multivesicular bodies （MVBs）, which contains plasma membrane, membrane protein and functional signaling protein. The variety of proteins depends on the origin of EXO and thus imparts distinct biological function. Exosomes derived from antigen-presenting cells （APC）, such as dendritic cells, and tumor cells may play an important role in immunological regulation and cancer immunotherapy. The present review summarizes the recent studies of EXO-related biological function. |
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| Keywords: | Dendritc cell Tumor cell Exosomes Cancer immunoterapy |
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