| 三磷酸腺苷-氯化镁对实验性急性呼吸窘迫综合征的治疗作用 |
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| 引用本文： | 安昌善,朴红梅,金明根,夏书香.三磷酸腺苷-氯化镁对实验性急性呼吸窘迫综合征的治疗作用[J].中国急救医学,1999,19(9):528-529. |
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| 作者姓名： | 安昌善 朴红梅 金明根 夏书香 |
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| 作者单位： | 延边大学医学院附属医院呼吸内科,吉林,延吉,133000 |
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| 摘 要： | 目的 研究三磷酸腺苷—氯化镁对油酸性急性呼吸窘迫综合征保护作用。方法 以２１ 只大白鼠为实验动物，建立油酸型急性呼吸窘迫综合征模型。随机分为三组：正常组、损伤组及治疗组。观察肺组织病理改变，动脉血氧分压及血浆丙二醛变化。结果 三磷酸腺苷—氯化镁治疗组的病理改变比损伤组明显减轻；治疗组动脉血氧分压高于损伤组（ Ｐ＜００１） ；而治疗组血浆丙二醛水平低于损伤组（ Ｐ＜ ００１） 。结论 三磷酸腺苷—氯化镁对实验性急性呼吸窘迫综合征有一定的治疗作用。
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| 关 键 词： | 急性呼吸窘迫综合征 三磷酸腺苷 氯化镁 大鼠 |
| 文章编号： | 1002-1949(1999)09-0528-02 |
Therapeutic effect of ATP-magnesium chloride on experimental acute respiratory distress syndrome |
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| AN Chang-shan,PIAO Hong-mei,JIN Ming-gen,XIA Shu-xiang.Therapeutic effect of ATP-magnesium chloride on experimental acute respiratory distress syndrome[J].Chinese Journal of Critical Care Medicine,1999,19(9):528-529. |
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| Authors: | AN Chang-shan PIAO Hong-mei JIN Ming-gen XIA Shu-xiang |
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| Abstract: | Objective To investigate the therapeutic effects of ATP-magnesium chloride on experimental acute respiratory distress syndrome.Methods 21 rats were divided into 3 groups:control group,oleic acid group and ATP-magnesium chloride-treated group.Acute respiratory distress model was produced by intravenous injection of oleic acid.Results PaO 2 in ATP-megnesium chloride-treated group was higher than that in oleic acid group ( P< 0 01);MDA in ATP-megnesium chloride-treated group was decreased significantly as compared with that in oleic acid group;Histologic injury in ATP-megnesium chloride-treated group was significantly improved as compared with that in oleic acid group.Conclusion ATP-magnesium chloride might have a therapeutic effects on the oleic acid-iuduced acte respiratory distress syndrome. |
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| Keywords: | Acute respiratory distress syndrome Adenosine triphosphate Magnesium chloride Rat |
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