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Rapid appearance of plasmin in tear fluid after ocular allergen exposure.
Authors:E M Salonen   J Lauharanta   P S Sim   R Stephens     A Vaheri
Affiliation:Department of Virology, University of Helsinki, Finland.
Abstract:Specific allergens were applied topically to the conjunctivae of 18 allergic patients. In cases with positive allergic reaction, proteolytic activity, identified as plasmin using zymographic analysis and a monoclonal anticatalytic antibody to plasmin, was found to appear within 3-5 min in the tear fluid, reaching concentrations of 2.2-28.6 micrograms/ml. No plasmin was detected, either in the tear fluid of 30 unchallenged non-atopic control persons, or atopic patients provoked with a test material that had given no reaction in a skin prick test. These findings suggest that generation of plasmin is a consequence of the conjunctival allergic reaction.
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