Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis |
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Authors: | Djuri? Tamara Zivkovi? Maja Radak Djordje Jeki? Djole Radak Sandra Stojkovi? Ljiljana Raicevi? Ranko Stankovi? Aleksandra Alavanti? Dragan |
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Institution: | VINCA Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics, P.O. Box 522, 11001 Belgrade, Serbia. tamariska@vin.bg.ac.yu |
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Abstract: | ObjectivesStromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low- and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population.Design and methodsThe study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR.ResultsThere was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p < 0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI = 1.0–5.5, p = 0.048).ConclusionsSubjects carrying genotypes with 6A allele had significantly higher susceptibility to carotid atherosclerosis. |
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