儿童1型糖尿病血脂异常的临床分析

目的分析31例儿童1型糖尿病的血脂特点以及与血糖控制的关系。方法将我院31例1型糖尿病患儿分成DKA组(n=12)和非DKA组(n=19),比较两组空腹血糖、糖化血红蛋白、三酰甘油、总胆固醇、高密度脂蛋白和低密度脂蛋白有无差异;根据血脂分为异常组(n=18)和正常组(n=13),比较两组DKA发生、病程、空腹血糖及糖化血红蛋白差异;分析糖化血红蛋白与三酰甘油、总胆固醇、高密度脂蛋白及低密度脂蛋白的关系。结果 DKA组和非DKA组的空腹血糖、三酰甘油和低密度脂蛋白差异有统计学意义(P<0.05);糖化血红蛋白、总胆固醇及高密度脂蛋白的差异无统计学意义(P>0.05)。血脂异常组和血脂正常组发生DKA的百分比分别是55.56%和15.38%,两者差异有统计学意义(P<0.05),但是两组间病程、空腹血糖和糖化血红蛋白差异无统计学意义(P>0.05)。TC、TG不随HbA1c的升高而升高(P>0.05),HDL随HbA1c升高而降低(P<0.05)。结论 1型糖尿病患儿合并DKA者三酰甘油明显升高,血脂异常组更易发生DKA。

The clinical analysis of lipid levels in children with type 1 diabetes

Objective To study the feature of lipid levels in children with type 1 diabetes mellitus(T1DM).Methods The 31 children with T1DM were respectively divided into DKA group(n=12) and Non-DKA group(n=19),and found out the differences of fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC) and triglyceride(TG),high density lipoproteins(HDL),low density lipoproteins(LDL) between two groups;the patients were divided into dyslipidemia group(n=18) and ortholiposis group(n=13),and to compare the incidence of DKA and the differences of FBG and HbA1c;To analyze the correlation between HbA1c,TC,TG,HDL and LDL.Results There were significant differences in FBG,TG and LDL between DKA group and Non-DKA group(P<0.05),while HbA1c,TC and HDL were without significantly differences(P>0.05).The percent of DKA is 55.56% in dyslipidemia group and is 15.38% in ortholiposis group,the two groups have significant differences(P<0.05),but there were not significant differences in pathogenesis,FBG and HbA1c(P>0.05).TC,TG,LDL did not increase with increasing HbA1c(P>0.05),HDL decreased with increasing HbA1c(P<0.05).ConclusionTG of DKA group in children with T1DM is apparently higher than that of non-DKA group.DKA occurs more often in dyslipidemia group.