| 顺铂经支气管动脉灌注——临床药代动力学规律的初步研究 |
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| 引用本文： | 唐永平 黄德平. 顺铂经支气管动脉灌注——临床药代动力学规律的初步研究[J]. 现代诊断与治疗, 1992, 3(2): 199-202 |
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| 作者姓名： | 唐永平 黄德平 |
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| 作者单位： | 同济医科大学附属协和医院，空军汉口中心医院肿瘤科，同济医科大学附属协和医院，同济医科大学实验中心分析室，同济医科大学实验中心分析室 研究生 中国人民解放军第九十四医院放射科 |
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| 摘 要： | 6例晚期肺癌病人经支气管动脉灌注(BAI)顺铂,另2例经肘静脉灌注顺铂。取血样后用极谱法测定顺铂的血药浓度,行药代动力学分析。结果表明顺铂两种方式给药,药代动力学均表现为二房室模型。经支气管动脉注药病人血液中游离铂的浓度高于经静脉注药病人血中的浓度,前者血中游离铂的消除相半衰期也长于后者。文章讨论了这种差异可能的原因及其临床意义。
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| 关 键 词： | 顺铂 肺癌 支气管动脉注药 药代动力学 |
A preliminary study on the pharmacokinetics of Cisplatin after bronchial arterial infusion (BAI) |
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| Tang Yongping,et al Radiological Department,th Hospital of PLA. A preliminary study on the pharmacokinetics of Cisplatin after bronchial arterial infusion (BAI)[J]. Modern Diagnosis & Treatment, 1992, 3(2): 199-202 |
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| Authors: | Tang Yongping et al Radiological Department th Hospital of PLA |
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| Affiliation: | Tang Yongping,et al Radiological Department,94th Hospital of PLA |
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| Abstract: | Cisplatin was infused into bronchial artery (BAI) in six patients with advanced lung cancer and into median cubital vein in other two patients. The concentration of cisplatin in blood was determined by polarographic method for pharmacokinetic study of the agent. The blood drug--time curves of ofter infusing cisplatin by different route. were conformed to two-conpartment open model. The concentration of free cisplatin in plasma of patients after BAI was higher than that of patients after intravenous infusion, and the terminal half life period (t1/2β) is longer in patients by BAI than that in petients infused by vein. |
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| Keywords: | Cisplatin Lung cancer Bronchial artery infusion (BAI) Pharmacokinetics |
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