精神分裂症的抑郁症状及其与疗效的关系

目的了解急性期住院精神分裂症患者伴发抑郁症状的影响因素以及抑郁症状与治疗结果间的关系。方法对符合CCMD-3诊断标准的精神分裂症患者75例，分别于入院3天内及每2周评定PANSS、HAMD、TESS量表，持续8周。结果偏执型精神分裂症、多次住院、年龄较小、受教育的时间较少者易出现抑郁症状。治疗后汉密顿抑郁量表总分与一般精神病理量表、抑郁症状群、TESS正相关。治疗前HAMD评分与治疗8周末PANSS总分减分率正相关。结论精神分裂症不同阶段抑郁症状的发生率不同，急性期精神症状与抑郁症状同时出现时，患者的治疗效果较好。偏执型精神分裂症、多次住院、年龄较小、受教育的时间较少是分裂症患者出现抑郁症状的危险因素。

The relationship of depressive symptoms to the drug response of patients with schizophrenia

Objective: To understand the factors which influence the depressive symptoms of schizophrenia, and the effects of the depressive symptoms on treatment. Methods: To examine acute episode patients who met CCMD-3 criteria for schizophrenia with PANSS, HAMD, and TESS in three days after their admission and 2,4,6,8 weeks after treatment. Results:The patients who were young, with the diagnosis of paranoid schizophrenia, had more admission times and less education had more risks to suffer from depression. At the end of eight weeks treatment, the baseline HAMD scores were correlated positively with the rate of PANSS total scores' subtraction. Conclusion:The prevalence of depressive symptoms in schizophrenia at different stage is various. it would appear that the presence of depressive symptoms in the acute phase of the illness might be associated with a favorable treatment outcome. paranoid schizophrenia, more admission times, less education and young are the risk factors to depression in schizophrenia.