| 三维适形放疗联合顺铂治疗复发上颌窦癌的疗效观察 |
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| 引用本文： | 李甸源,高松涛,周志刚,师国珍.三维适形放疗联合顺铂治疗复发上颌窦癌的疗效观察[J].医药论坛杂志,2009(8). |
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| 作者姓名： | 李甸源 高松涛 周志刚 师国珍 |
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| 作者单位： | 郑州大学第一附属医院放疗科; |
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| 摘 要： | 目的观察顺铂(DDP)联合三维适形放疗(3DCRT)对局部复发上颌窦癌的放射增敏作用。方法66例复发者均为首程放疗后达其本痊愈或明显好转,一段时间(>8个月)后又出现鼻涕、鼻塞、疼痛、面部肿胀等情况恶化的临床症状,经病理检查确诊为复发,随机分为研究组和对照组,每组33例。研究组DDP20mg/m2用生理盐水250ml稀释后静脉滴注,滴注结束后50min内放疗,放疗均采用西门子直线加速器,6mV-X线,BrainLAB公司三维治疗计划系统行三维适形放疗(3DCRT)。3～5Gy/次,4～5次/周。照射剂量研究组45～50Gy、对照组55～60Gy。采用SCT和MRI比较两组近期疗效,并比较两组不良反应差别。结果研究组近期有效率(CR+PR)为73%,对照组为42%。两组不良反应发生率中白细胞下降,Ⅲ度以上口腔黏膜反应,脑水肿症状分别为24%(8/33)、3%(1/33)、24%(8/33)、和21%(7/33)、18%(6/33)、18%(6/33)(P<0.05)。结论DDP可增加局部复发上颌窦癌的放射敏感性,表现为在降低放疗剂量的情况下,提高了复发上颌窦癌的近期疗效且不增加不良反应。
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| 关 键 词： | 三维适形放疗 复发上颌窦癌 顺铂 |
Cisplatin Radiosensitization in Re-radiotherapy for Locally Recurrent Maxinary Sinus Carcinoma |
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| LI Dianyuan,GAO Songtao,ZHOU Zhigang,et al.Cisplatin Radiosensitization in Re-radiotherapy for Locally Recurrent Maxinary Sinus Carcinoma[J].Journal of Medical Forum,2009(8). |
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| Authors: | LI Dianyuan GAO Songtao ZHOU Zhigang |
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| Institution: | LI Dianyuan,GAO Songtao,ZHOU Zhigang,et al Department of Radiation Oncology,1st hospital of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To investigate the radiosensitive effect of three dimensional conformal radiotheraphy and cisplatin(DDP) against locally recurrent maxinary sinus carcinoma.Methods All sixty-six recurrences basically recoverd or turned for the better after the 1st radiotherapy.After a period of time(>8months),these patients had the deterioration symptoms:nasal mucus,snuffle,pain,facial swelling and so on,and they were diagnosised as the recurrence after the pathological examination.Then,these 66 patients were rand... |
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| Keywords: | Tree dimensional conformal radiotheraphy Cisplatin Maxinary sinus carcinoma |
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