| 食管癌APC/MCC基因杂合缺失的研究 |
| |
| 引用本文： | 王明荣,王海东,熊刚,房殿春.食管癌APC/MCC基因杂合缺失的研究[J].第三军医大学学报,2000,22(7):653-655. |
| |
| 作者姓名： | 王明荣 王海东 熊刚 房殿春 |
| |
| 作者单位： | 第三军医大学附属西南医院胸心外科,重庆,400038 |
| |
| 摘 要： | 目的 研究ＡＰＣ／ＭＣＣ基因杂合性缺失（ＬＯＨ）与食管癌发生发展的关系。方法 多聚酶锭反应技术及限制性片段长度多态现象对４６例食管癌ＡＰＣ和ＭＣＣ基因的ＬＯＨ进行了分析。结果 食管癌ＡＰＣ和ＭＣＣ基因ＬＯＨ阳性表达分别为２９．０％和３３．３％。结论ＡＰＣ、ＭＣＣ基因的ＬＯＨ是食管癌的常见改变，可能参与了食管癌的发生。
|
| 关 键 词： | 食管肿瘤 抑癌基因 杂合缺失APC／MCC |
Loss of heterozygosity at APC and MCC genetic loci in esophageal carcinoma |
| |
| WANG Ming-rong,WANG Hai-dong,XIONG Gang,FANG Dian-chun.Loss of heterozygosity at APC and MCC genetic loci in esophageal carcinoma[J].Acta Academiae Medicinae Militaris Tertiae,2000,22(7):653-655. |
| |
| Authors: | WANG Ming-rong WANG Hai-dong XIONG Gang FANG Dian-chun |
| |
| Abstract: | Objective To study the relationship between the loss of heterozygosity (LOH) at APC and MCC genetic loci and the incidence and development of esophageal carcinoma. Methods LOH at APC and MCC genetic loci in 46 specimens resected from esophageal neoplasm was studied with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results LOH was 29.0% and 33.3% at APC and MCC genetic loci, respectively. Significant correlation was found between LOH at genetic loci and clinical parameters ( P >0.05). Conclusion This study suggests that LOH at APC and MCC genes is the common genetic alteration in esophageal carcinoma and may participate in the genesis of esophageal carcinoma. |
| |
| Keywords: | neoplasma esophageal carcinoma suppressor gene loss of heterozygosity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
