老年高血压病患者血管内皮功能与氧化低密度脂蛋白变化关系的探讨

目的探讨老年高血压患者血管内皮功能与氧化低密度脂蛋白变化关系，寻求较好的治疗方法。方法按WHO高血压诊断标准，选择年龄为60—72岁的Ⅱ期老年高血压患者60例，与30例正常健康者进行对照，比较两组一般特点，同时检测氧化低密度脂蛋白（OX—LDL）、内皮依赖舒张因子（NO），血管内皮素（ET），血管内皮细胞计数（CEC）。结果两组结果显示，正常对照组与高血压组在年龄，性别组成方面无显著差异，但两组的血压比较则有显著差异（P〈0．001），高血压组的OX—LDL、ET、CEC结果均高于正常对照组，NO结果则低于正常对照组。结论本研究结果提示与Ⅱ期老年高血压发生发展有肯定关系，提示临床在治疗中不仅注重血管内皮功能保护，同时加强抗氧化治疗，延缓高血压发展。

Discussion of the Relationship between Vascular Endothelium Function and OX-LDL Change in Senile Patients with Hypertension

Objective To discuss the relationship between vascular endothelium function and OX-LDL change in senile patients with hypertension so as to find out better treatment.Methods 60 senile patients with Hypertension at Stage II were selected as the hypertension group,and 30 normal cases were chosen as the control;a comparison between the 2 groups was made in general and the OX-LDL,NO, ET CEC was detected.Results There was no obvious difference in age and sex between the 2 groups,there existed a significant difference in blood pressure between the 2 groups(P<0.001);the OX-LDL,ET and CEC of hypertension group were higher than those of the control while the NO was lower than that in the control.Conclusions The research indicates that vascular endothelium function and OX-LDL change has positive relation with Hypertension at Stage II in senile patients,the protection of vascular endothelium function should be paid attention and antioxygen treatment should be given so as to delay the progress of hypertension.