| 流式细胞术相关性分析急性髓系白血病p21（H－ras）与DNA倍体 |
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| 引用本文： | 林凤茹,任金海,李小梅,刘素云,卫俊萍,姚尔固,徐世荣,刘润生.流式细胞术相关性分析急性髓系白血病p21（H－ras）与DNA倍体[J].白血病．淋巴瘤,1996(2). |
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| 作者姓名： | 林凤茹 任金海 李小梅 刘素云 卫俊萍 姚尔固 徐世荣 刘润生 |
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| 作者单位： | 河北医科大学附二院 |
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| 摘 要： | 用流式免疫法分析３０例初治急性髓系白血病（ＡＭＬ）细胞ｒａｓ癌基因产物ｐ２１蛋白和ＤＮＡ倍体的关系。发现ｐ２１表达阴性者１７例，阳性者１３例。ｐ２１阳性者骨髓与外周血原始细胞百分比较高，外周白细胞数较低。ｐ２１表达不影响疗效。ｐ２１阳性及ＣＲ期有异倍体者易复发。认为ｐ２１对白血病发生、发展有一定作用。
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| 关 键 词： | p21（H－ras）癌基因 DNA倍体 流式细胞术 急性髓系白血病 |
CORRELATED FLOW CYTOMETRIC ANALYSIS OF P21(H-RAS)AND DNA PLOIDY IN ACUTE MYELOGENOUS LEUKEMIA |
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| Lin Fengru, Ren Jinhai, Li Xiaomei, et al.CORRELATED FLOW CYTOMETRIC ANALYSIS OF P21(H-RAS)AND DNA PLOIDY IN ACUTE MYELOGENOUS LEUKEMIA[J].Journal of Leukemia & Lymphoma,1996(2). |
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| Authors: | Lin Fengru Ren Jinhai Li Xiaomei |
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| Abstract: | We used flow cytometric immunoassay to study the correlation between H-rasoncogene product p 21 and DN A ploidy in 30 de novo cases of acute myelogenous leukernia(AML).The results showed that 17 cases were negative and 13 positive in the oxprossion ofp21.The patients with positive p21 had higher percentage of bone marrow and peripheral blastsand lower peripheral leukocyte count. The expression of p 21 had no influence on completeremission rate. Patients with p21 or aneuploidy in complete remission were at risk for earlyrelapse. We think that p21 may be involved in the process of leukemogenesis and progression of AML. |
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| Keywords: | Ras oncogene product p21 DNA Ploidy Flow cytometry Acute myelogenous leukemia |
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