Reduced adenosine 3',5'cyclic monophosphate levels in patients with reversible obstructive airways disease |
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| Authors: | J. J. Krzanowski J. B. Poison A. L. Goldman T. A. Ebel A. Szentivanyi |
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| Affiliation: | Department of Pharmacology and Therapeutics, and Pulmonary Disease Section, Department of Internal Medicine, University of South Florida, College of Medicine, Tampa, Florida, U.S.A. |
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| Abstract: | 1. Patients were grouped into categories of ‘no airways disease’, ‘obstructive airways disease without response to bronchodilator’ and ‘obstructive airways disease with bronchodilator responsiveness’. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of adenosine 3′,5′-cyclic monophosphate (cyclic AMP) were found in pulmonary tissue obtained from patients with reversible obstructive airways disease, lending support to the β-adrenergic theory of asthma. |
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| Keywords: | adenosine 3',5'-cyclic monophosphate cyclic AMP cyclic GMP guanosine 3',5'-cyclic monophosphate human lung |
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