河北省2009-2010年细菌性脑膜炎哨点监测病例分析

目的初步了解河北省细菌性脑膜炎流行病学特征和病原情况。方法选择6家哨点医院,开展细菌性脑膜炎病例流行病学调查和实验室病原检测。结果 2009-2010年哨点医院共报告细菌性脑膜炎病例134例,死亡1例。发病以15岁以下散居儿童和学生为主,男性多于女性,本地病例占1/2左右,冬春季节和7~8月为发病高峰,病例以轻型和不典型为主。从96例病例脑脊液标本中分离出Sp 1株,Hib 1株,其他菌5株。96例病例标本的Real-time PCR检测Sp阳性4例,Hib阳性2例,阴性90例。结论哨点医院报告病例数较少,病原检测阳性率低,需进一步分析查找原因。

Analysis of bacterial meningitis cases in sentinel points of Hebei province during 2009 to 2010

Objective To preliminary understand the epidemic characteristics and etiology of bacterial meningitis in Hebei province.Method 6 hospitals were selected as bacterial meningitis surveillance sentinel point,and developed cases epidemiological survey and etiology detection.Results 134 bacterial meningitis cases were reported during 2009 to 2010 and 1 case died.The patients were mainly scattered children and students under 15 years old,males were more than females,and half cases were natives.The peak times of the disease were winter,spring and July to August.Clinical symptom of majority cases was not serious.1 Sp,1 Hib and 5 other bacterial strains were isolated from 96 cerebrospinal fluid（CSF） samples.Detected by real time PCR,4 cases were Sp positive,2 cases were Hib positive and 90 cases were negative.Conclusions Reported bacterial meningitis cases in sentinel hospitals were less and the positive result of etiology detection were low too,and need to analyze and find out the reasons.