| 奥氮平对甲状腺激素水平的影响 |
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| 引用本文： | 张传海,周建敏,贺朝晖,徐建龙,吴鹏飞.奥氮平对甲状腺激素水平的影响[J].临床精神医学杂志,2010,20(2):121-122. |
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| 作者姓名： | 张传海 周建敏 贺朝晖 徐建龙 吴鹏飞 |
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| 作者单位： | 1. 昆山市第三人民医院精神科,215316
2. 昆山市第三人民医院内科 |
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| 基金项目： | 2008年昆山市社会发展科技计划指令性项目([2008]79-22) |
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| 摘 要： | 目的：了解奥氮平对精神分裂症患者甲状腺素水平的影响。方法：随机抽取正在服用奥氮平的住院精神分裂症患者20例，分别于入组时、入组后1个月查FT3、FT4、TSH并进行比较。结果：入组时与常模比较FT3显著下降（P〈0．01）；1个月后与常模比较FT3、FT4显著下降（P〈0．01）；入组时与1个月后比较FT4显著下降（P〈0．01）；TSH与年龄、剂量、服用时间正相关（r〉0．3）；FIB、FT4、TSH与性别无相关性。结论：奥氮平可致甲状腺激素水平下降，TSH有反馈性升高趋势，但尚在正常范围内。临床或许可以通过干预甲状腺激素水平来调整精神分裂症患者的情绪障碍。
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| 关 键 词： | 奥氮平 精神分裂症 甲状腺激索 |
Effect of olanzapine on thyroid hormones in schizophrenic patients |
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| ZHANG Chuan-hai,ZHOU Jian-min,HE Zhao-hui,XU Jian-long,WU Peng-fei.Effect of olanzapine on thyroid hormones in schizophrenic patients[J].Journal of Clinical Psychological Medicine,2010,20(2):121-122. |
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| Authors: | ZHANG Chuan-hai ZHOU Jian-min HE Zhao-hui XU Jian-long WU Peng-fei |
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| Institution: | ZHANG Chuan-hai,ZHOU Jian-min,HE Zhao-hui,XU Jian-long,WU Peng-fei.Third People's Hospital of Kunshan,Kunshan 215316,China |
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| Abstract: | Objective:To understand the effect of olanzapine on the levels of thyroid hormones in schizophrenic patients. Method:Twenty inpatients with schizophrenia who received olanzapine therapy were selected randomly and tested FT3,FT4,TSH at the beginning of treatment and after 1 month treatment. Results:Compared with the norm,FT3 level of the patients decreased significantly at the beginning of treatment(P<0.01),and FT3,FT4 levels decreased significantly after 1 month treatment(P<0.01).FT4 level decreased more si... |
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| Keywords: | olanzapine schizophrenia thyroid hormones |
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