Mast cells, TGF-beta1 and alpha-SMA expression in IgA nephropathy |
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| Authors: | Silva G E B Costa R S Ravinal R C dos Reis M A Dantas M Coimbra T M |
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| Affiliation: | 1.Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil;2.Department of General Pathology, Faculty of Medicine of Triângulo Mineiro, Uberaba, MG, Brazil;3.Division of Nephrology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil;4.Department of Physiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil |
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| Abstract: | IgA nephropathy (IgAN) is a kidney disease with a varying renal prognosis. Recently, many studies have demonstrated that renal alpha-smooth muscle actin (alpha-SMA) and transforming growth factor (TGF-beta1) expression, as well interstitial mast cell infiltrates could represent a prognostic marker in several renal diseases. The aim of our study was to analyze the prognostic value of mast cell, TGF-beta1 and alpha-SMA expression in IgAN. A survey of the medical records and renal biopsy reports of 62 patients with a diagnosis of IgAN followed-up from 1987 to 2003 was performed. The mean follow-up time was 74.7 +/- 50.0 months. The immunohistochemical studies were performed using a monoclonal antibody anti-human mast cell tryptase, a polyclonal antibody anti-human TGF-beta1, and a monoclonal antibody anti-human alpha-SMA. An unfavorable clinical course of IgAN was related to interstitial mast cell infiltrates and alpha-SMA expression in the tubulointerstitial area. Expression of glomerular TGF-beta1 and alpha-SMA, and interstitial TGF-beta1 is not correlated with clinical course in IgAN. In conclusion, the increased number of mast cells and higher alpha-SMA expression in the tubulointerstitial area may be predictive factors for the poor prognosis of patients with IgAN. |
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| Keywords: | Iron stores thrombolysis ferritin biomarkers excitotoxicity blood-brain-barrier disruption inflammation |
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