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| 防风与刺蒺藜的药理实验研究 | |
| 引用本文： | 陈子珺,李庆生,李云森,淤泽溥,袁嘉丽,李仪奎.防风与刺蒺藜的药理实验研究[J].中成药,2003,25(9):737-739. |
| 作者姓名： | 陈子珺 李庆生 李云森 淤泽溥 袁嘉丽 李仪奎 |
| 作者单位： | 1. 上海中医药大学中药药理毒理中心,上海,200032;云南中医学院,云南,昆明,650200 2. 云南中医学院,云南,昆明,650200 3. 中国科学院上海药物研究所,上海,200031 4. 上海中医药大学中药药理毒理中心,上海,200032 |
| 摘 要： | 目的：研究防风与刺蒺藜单用及合用的药理作用。方法：运用右旋糖酐及组胺造成搔痒模型，组胺引起毛细血管通透性增高。二甲基亚飘引起接触性荨麻疹，观察药物作用。结果：防风、刺蒺藜、防刺合煎剂对外源性组胺和右旋糖酐诱导内源性组胺动物搔痒模型均有显著的止痒作用，能明显抑制组胺引起的毛细血管通透性增高，能不同程度地抑制二甲基亚飘所致的豚鼠耳肿胀。结论：防风、朝蒺藜、防刺合煎剂有抗过敏作用，防风与朝蒺葶合用的效应较两药单用强。 |
| 关 键 词： | 防风 刺蒺藜 止痒 抗过敏 小鼠 豚鼠 |
| 文章编号： | 1001-1528(2003)09-0737-02 |
| 修稿时间： | 2003年1月15日 |
Pharmacodynamics study on Radix saposhnikoviae(RL) and Feutus tribuli(FI) |
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| CHEN Zi jun ,LI Qing sheng ,LI Yun sen ,Yu Ze fu ,YUAN Jia li ,LI Yi kui.Pharmacodynamics study on Radix saposhnikoviae(RL) and Feutus tribuli(FI)[J].Chinese Traditional Patent Medicine,2003,25(9):737-739. | |
| Authors: | CHEN Zi jun LI Qing sheng LI Yun sen Yu Ze fu YUAN Jia li LI Yi kui |
| Institution: | CHEN Zi jun 1,2,LI Qing sheng 2,LI Yun sen 3,Yu Ze fu 2,YUAN Jia li 2,LI Yi kui 1 |
| Abstract: | Objective: To study the pharmacological effects of Radix Saposhnikoviae (RL) and Fruetus Tribuli (FI) used singly and combinedly. Methods: The effect of the tested drugs on the animal itching models induced by dextran 40 and Histanmine, skin capillary permeability induced by Histamine and experimental nettle rash induced by dimethylsulfoxide (DMSO) were observed. Results: RL and FI used singly and combinedly could obviously relieve the itch, inhibit the increase of skin capillary permeability induced by Histamine and resist experimental nettle rash induced by dimethylsulfoxide (DMSO) in different degree. Conclusion:RL and FI used singly and combinedly have anti allergic effect and the effect of RL and FI used combinedly is the same as used respectively. |
| Keywords: | Radix Saposhnikoviae Frutus Tribuli relieve itching anti allergic effect mouse guinea pig |
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