光损伤早期视网膜感光细胞的病理改变

目的：探讨光损伤早期视网膜感光细胞病理改变的特征。方法：健康无眼病SD大鼠15只，随机分为3组，其中1组不接受光照作为正常对照组，另外2组为实验组，分别以2800Lux强度白光持续照射3h和6h造成视网膜光损伤，采用透射电镜观察视网膜感光细胞的病理改变。结果：持续光照6h大鼠的视网膜感光细胞出现显著的病理改变，主要表现为核固缩、染色质边集、核膜内陷以及线粒体和外节膜盘正常结构的破坏。结论：光损伤早期视网膜感光细胞的超微结构即受到破坏并发生凋亡。

Pathological changes of photoreceptors at the early stage of light injury

Aim: To investigate the pathological features of photoreceptors at the early stage after light-induced retina injury. Methods: Fifteen SD rats without any eye disease were randomly allocated into 3 groups.One group which was not exposed to light was taken as normal control. The other 2 groups (experimental groups) were induced retinal light injury by exposed to constant white light with intensity of 2 800 Lux for 3 h or 6 h, respectively. The pathological changes of photoreceptors were observed under transmission electron microscope. Results: After 6 h exposure, obvious pathologic changes including nuclear shrinkage, chromatin margination, nuclear notch and the destruction of the mitochondria and outer segment membrane disc were observed in the photoreceptors. Conclusion: At the early stage of light-induced retina injury, photoreceptors develop ultrastructural destructions and result in apoptosis.