5-羟色胺转运体基因第二内含子多态性与强迫症的关联分析

目的　探索上海地区汉族人口中 5 羟色胺转运体 ( 5 HTT)基因第二内含子多态性与强迫症的关系。方法　采用聚合酶链反应扩增片段长度多态 (PCR AmFLP)技术测定 10 2例强迫症 (OCD)患者和 110名健康对照的基因型。结果　强迫症患者 5 HTT第二内含子基因型与等位基因分布与健康对照之间均存在显著性差异 (P <0 0 5 ) ;等位基因 10和 12 / 10基因型与强迫症存在显著正关联 (OR值分别为 2 4 5和 2 4 2 ,P <0 0 5 )。结论　汉族人群中 5 HTT基因第二内含子多态性与强迫症的发病可能有遗传关联 ,等位基因 10和 12 / 10基因型可能是强迫症的风险因子

An analysis on the relationship between polymorphism of intron 2 in serotonin transporter gene and obsessive-compulsive disorder

Objective To explore the relationship between polymorphism of intron 2 in serotonin transporter(5 HTT) gene and obsessive compulsive disorder(OCD) in the Han nationality of Shanghai. Methods 102 OCD patients and 110 health controls were took prat in this study. All subjects were genotyped directly via polymerase chain reaction amplification fragment length polymorphism techniques. Results There were significant difference of genotype and allele frequencies of intron 2 of 5 HTT gene between patients and controls. Allele 10 and 12/10 genotype were significantly positively associatied with OCD. Conclusions The results suggested that the polymorphism of intron 2 of 5 HTT gene maybe associated with OCD in the Han nationality. With allele 10 or 12/10 genotype may bea risk factor for OCD.