吸虫排泄分泌产物成分及其功能的研究进展

吸虫是一类重要的人兽共患寄生虫,不仅影响水产业和家畜业的生产,还严重威胁人类的健康.吸虫的排泄分泌产物(excretory-secretory products,ESP)在虫体致病机制中发挥重要的作用,研究其组成成分和相应的功能对探讨虫体和宿主的相互关系有重要的意义.目前已开展通过蛋白质组学和基因组学的相关技术对ESP的成分进行分离、提纯、重组表达,并在体内、外探讨各生物活性分子的生物活性和免疫调节功能的研究.该文就吸虫排泄分泌产物及功能的国内外研究进展作一综述.

Research progress on the components and functions of excretory-secretory products of trematode

Trematode is an important class of parasitic zoonosis not only affecting the production of aquaculture and livestock industry, but also seriously threatening human health. Excretory-secretory products (ESP) of trematode play an important role in the pathogenic mechanisms. Studying its composition and the corresponding function is of great significance for understanding the relationship between parasite and host. At present, using proteomics and genomics-related technology, many studies are involved in the purification/separation/re-expression of the ESP and the biological activity and immune function of the various elements in vivo or in vitro. In this paper, the research progress on the components and functions of ESP of trematode was reviewed.